Partial liquid ventilation in adult patients with acute respiratory distress syndrome
Partial liquid ventilation in adult patients with acute respiratory distress syndrome
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DOI：
10.1164/rccm.200508-1196oc
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发表时间：
2006-04-15
影响因子：
24.7
通讯作者：
Slutsky, AS
中科院分区：
文献类型：
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作者：
Kacmarek, RM;Wiedemann, HP;Slutsky, AS
原理：尽管最近的临床试验表明急性呼吸窘迫综合征（ARDS）的结局有所改善，但死亡率仍然很高。在各种动物模型中，使用全氟化碳的部分液体通气（PLV）已被证明可改善氧合并减少肺损伤。目的：确定PLV是否对ARDS患者的结局有影响。方法：将ARDS患者随机分为（1）常规机械通气组和（2）常规机械通气组，（CMV; n = 107），（2）“低剂量”全氟化碳（10 ml/kg; In = 99），和（3）“高剂量”全氟化碳（20 ml/kg; n = 105）。三组患者均采用容量通气，V-t
Rationale: Despite recent clinical trials demonstrating improved outcome in acute respiratory distress syndrome (ARDS), mortality remains high. Partial liquid ventilation (PLV) using perfluorocarbons has been shown to improve oxygenation and decrease lung injury in various animal models.Objective: To determine if PLV would have an impact on outcome in patients with ARDS.Methods: Patients with ARDS were randomized to (1) conventional mechanical ventilation (CMV; n = 107), (2) "low-dose" perfluoro-carbon (10 ml/kg; In = 99), and (3) "high-dose" perfluorocarbon (20 ml/kg; n = 105). Patients in all three groups were ventilated using volume ventilation, V-t