BOUND SODIUM IN ARTERY WALL
BOUND SODIUM IN ARTERY WALL
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DOI：
10.1152/ajplegacy.1960.199.5.783
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发表时间：
1960-01-01
影响因子：
--
通讯作者：
BOHR, DF
中科院分区：
文献类型：
--
作者：
HEADINGS, VE;RONDELL, PA;BOHR, DF
对犬颈动脉总钠、钾、氯含量及菊糖间隙进行了分析。Ki/Ko梯度为125/4。根据这些分析计算的钠空间大于总水合，因此排除了Nai/Nao梯度的计算。据推测，过量的钠与动脉壁介质间隙中存在的粘多糖有关。在Krebs溶液中孵育动脉壁培养基3分钟期间，这种相关的钠容易被替换，其中氢或钾浓度增加。由于孵育组织中的氯化物浓度远大于该平衡所需的计算值，因此大部分过量钠似乎不太可能归因于唐南平衡。
Analyses were made of total sodium, potassium and chloride content and of inulin space in dog carotid artery. The Ki/Ko gradient was found to be 125/4. Sodium space calculated from these analyses is larger than total hydration, thus precluding calculation of the Nai/Nao gradient. It is postulated that the excess sodium is associated with the mucopolysaccharides present in the interstitial spaces of the artery wall media. This associated sodium is readily replaced during 3-minute incubation of the artery wall media in Krebs solution in which either the hydrogen or the potassium concentration is increased. It appears improbable that the majority of the excess sodium can be attributed to a Donnan equilibrium since chloride concentration in the incubated tissue is much greater than that calculated to be required for this equilibrium.