Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer
Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer
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DOI：
10.1016/s0002-9378(97)70380-6
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发表时间：
1997-06-01
影响因子：
9.8
通讯作者：
Berchuck, A
中科院分区：
文献类型：
--
作者：
Clifford, SL;Kaminetsky, CP;Berchuck, A
目的：本研究旨在确定p53肿瘤抑制基因的过度表达是否与早期子宫内膜癌的不良预后相关，以及p53过度表达频率的种族差异是否有助于观察到的生存率的种族差异。研究设计：对164名I期子宫内膜腺癌患者进行p53基因的免疫染色。突变型p53蛋白的过表达见于164例中的28例（17%），并与不良组织学分级（p = 0.003）和非类增生组织学表现（p = 0.06）相关。在黑人中过度表达的频率（15/44，34%）也是白人（13/117，11%）的三倍（p = 0.003）。164例中有15例（9%）复发，p53基因过表达的病例（28例中有5例，18%）复发率是正常表达病例（136例中有10例，7%）的两倍多。复发性疾病被认为是在6 44（14%）黑人相比，9 117（8%）whites.CONCLUSIONS：这些数据支持这一假设，即在改变的p53肿瘤抑制基因的频率差异有助于子宫内膜癌生存的种族差异。
OBJECTIVE: This study was conducted to determine whether overexpression of the p53 tumor suppressor gene is associated with poor outcome in early-stage endometrial cancers and whether a racial difference in the frequency of p53 overexpression contributes to the observed racial disparity in survival rates.STUDY DESIGN: Immunostaining for the p53 gene was performed in 164 women with stage I endometrial adenocarcinomas.RESULTS: Overexpression of mutant p53 protein was seen in 28 out of 164 (17%) cases and was associated with a poor histologic grade (p = 0.003) and a nonendometrioid histologic appearance (p = 0.06). Overexpression also was three times more frequent in blacks (15 out of 44, 34%) than in whites (13 out of 117, 11%) (p = 0.003). Recurrent disease developed in 15 out of 164 (9%) cases and was more than twice as frequent in cases when the p53 gene was overexpressed (5 out of 28, 18%) than in cases with normal expression (10 out of 136, 7%). Recurrent disease was seen in 6 out of 44 (14%) blacks compared to 9 out of 117 (8%) whites.CONCLUSIONS: These data support the hypothesis that differences in the frequency of alteration of the p53 tumor suppressor gene contribute to the racial disparity in endometrial cancer survival.