Image Quality Affects Macular and Retinal Nerve Fiber Layer Thickness Measurements on Fourier-Domain Optical Coherence Tomography
Image Quality Affects Macular and Retinal Nerve Fiber Layer Thickness Measurements on Fourier-Domain Optical Coherence Tomography
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DOI：
10.3928/15428877-20110324-01
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发表时间：
2011-05-01
影响因子：
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通讯作者：
Sadda, Srinivas
中科院分区：
文献类型：
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作者：
Huang, Jingjing;Liu, Xing;Sadda, Srinivas
背景和目的：探讨图像质量是否是傅里叶域光学相干断层扫描 (OCT) 上视网膜神经纤维层 (RNFL) 和黄斑厚度测量的重要决定因素。 患者和方法：本研究的 RNFL 和黄斑厚度组分别招募了 75 名和 56 名正常受试者。使用 3D OCT-1000（版本 3.01，Mark II；Topcon Corporation，东京，日本）和 Cirrus OCT（版本 3.0，型号 4000；Carl Zeiss Meditec, Inc.，都柏林，加利福尼亚州）对每个参与者进行三次扫描。每个参与者的扫描按照图像质量递增的顺序排列，这与 RNFL 和黄斑厚度相关。使用相同与不同、高与低图像质量指标进行亚组分析。 结果：较高的图像质量与 3D OCT-1000 上较大的 RNFL 厚度测量显着相关，并且当 Cirrus 设备上的信号强度小于 7 时。图像质量指标与 Cirrus OCT 上测量的黄斑厚度呈负相关，但在 3D OCT-1000 上则不然。结论：在评估从傅里叶域 OCT 设备获得的厚度测量值时，应考虑图像质量指标。
BACKGROUND AND OBJECTIVE: To investigate whether image quality is an important determinant of retinal nerve fiber layer (RNFL) and macular thickness measurements on Fourier-domain optical coherence tomography (OCT).PATIENTS AND METHODS: Seventy-five and 56 normal subjects were recruited in RNFL and macular thickness arms of the study, respectively. Each participant was scanned three times using both the 3D OCT-1000 (version 3.01, Mark II; Topcon Corporation, Tokyo, Japan) and the Cirrus OCT (version 3.0, Model 4000; Carl Zeiss Meditec, Inc., Dublin, CA). The scans for each participant were arranged in order of increasing image qualities, which were correlated with RNFL and macular thicknesses. Subgroup analyses were performed with identical versus different and high versus low image quality metrics.RESULTS: Higher image quality was significantly correlated with greater RNFL thickness measurements on the 3D OCT-1000, and when the signal strength was less than 7 on the Cirrus device. Image quality metrics were negatively correlated with measured macular thicknesses on Cirrus OCT but not on 3D OCT-1000.CONCLUSION: Image quality metrics should be considered when evaluating thickness measurements derived from Fourier-domain OCT devices.