Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: A randomized, double-blind, placebo-controlled trial
Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: A randomized, double-blind, placebo-controlled trial
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DOI：
10.1016/j.atherosclerosis.2011.06.007
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发表时间：
2011-11-01
期刊：
影响因子：
5.3
通讯作者：
Takazawa, Kenji
中科院分区：
文献类型：
--
作者：
Nakamura, Teppei;Mizutani, Jun;Takazawa, Kenji
目的：这项试验评估了酪蛋白水解产物含有乳源性肽，Val-Pro-Pro（VPP）和Ile-Pro-Pro（IPP），对中心血压和arterial stiffic.Methods的影响：一个随机，双盲，安慰剂对照试验进行了70名日本受试者年龄在50-69岁未经治疗的第一阶段高血压。他们被随机分配到两组，分别接受安慰剂片剂或含有3.4 mg VPP和IPP的活性片剂。在8周的干预开始和结束时，测量血流动力学参数，包括中心血压和肱踝脉搏波速度（baPWV），动脉僵硬度的标志物。（活性药物：-11.0 +/- 11.0 vs安慰剂：-4.5 +/- 9.6 mm Hg，P < 0.01）。在活性组中，baPWV的降低肱动脉收缩压（-73.9 ± 130.0 vs -8.4 ± 137.1 cm/s，P < 0.05）（-10.5 +/- 11.5 vs -3.9 +/- 9.6 mm Hg，P < 0.05）和径向平均血压（-7.3 +/- 8.9 vs -2.0 +/- 7.4 mm Hg，P < 0.01）显著高于安慰剂组。酪蛋白水解物中的VPP和IPP可改善高血压患者的中心SBP和baPWV，这表明VPP和IPP可能对动脉特性具有有益的影响。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Objective: This trial evaluated the effects of casein hydrolysate containing milk-derived peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), on central blood pressure and arterial stiffness.Methods: A randomized, double-blind, placebo-controlled trial was conducted in 70 Japanese subjects aged 50-69 years with untreated stage-I hypertension. They were randomly assigned to two groups, which received either placebo tablets or active tablets containing 3.4 mg of VPP and IPP. At the beginning and end of the 8-week intervention, hemodynamic parameters, including central blood pressure and brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, were measured.Results: A significant difference in changes in central systolic blood pressure between the groups was observed (active: -11.0 +/- 11.0 vs placebo: -4.5 +/- 9.6 mm Hg, P < 0.01). In the active group, reductions in baPWV (-73.9 +/- 130.0 vs -8.4 +/- 137.1 cm/s, P < 0.05), brachial SBP (-10.5 +/- 11.5 vs -3.9 +/- 9.6 mm Hg, P < 0.05), and radial mean blood pressure (-7.3 +/- 8.9 vs -2.0 +/- 7.4 mm Hg, P < 0.01) were significantly greater as compared with the placebo group.Conclusion: Casein hydrolysate containing VPP and IPP improves central SBP and baPWV in hypertensive subjects, which suggests VPP and IPP might have beneficial effects on arterial properties. (C) 2011 Elsevier Ireland Ltd. All rights reserved.