Mouse modifier genes in mammary tumorigenesis and metastasis.
Mouse modifier genes in mammary tumorigenesis and metastasis.
复制标题
小鼠乳腺肿瘤发生和转移中的修饰基因。
DOI：
10.1007/s10911-008-9089-1
复制
发表时间：
2008
影响因子：
2.5
通讯作者：
Hunter,KentW
中科院分区：
文献类型：
--
作者：
Winter,ScottF;Hunter,KentW
肿瘤的发生和转移是一个复杂的多步骤过程。除了促进癌症进展的众多体细胞突变之外，有大量证据表明个体的遗传背景不仅有助于整体癌症风险，而且还特别影响转移潜力。迄今为止，已经确定的少数人类易感基因并不能完全解释遗传性癌症风险，并且使用基于人群的研究发现额外的易感基因座是复杂的，耗时的和昂贵的。因此，我们和其他人使用了各种小鼠模型来鉴定新的候选易感基因。在这里，我们回顾了这些小鼠模型如何有助于我们理解遗传背景在修饰肿瘤发生和转移易感性中的作用。
Tumorigenesis and metastasis are complex multistep processes. In addition to the numerous somatic mutations that facilitate cancer progression, there is abundant evidence that an individual’s genetic background not only contributes to overall cancer risk, but also specifically influences metastatic potential. The handful of human susceptibility genes that have been identified thus far do not fully account for hereditary cancer risk, and the discovery of additional susceptibility loci using population based studies is complex, time-consuming and expensive. Therefore, we and others have used a variety of mouse models to identify novel candidate susceptibility genes. Here we review how these mouse models have contributed to our understanding of the role of genetic background in modifying tumorigenesis and metastasis susceptibility.