DEVELOPMENT OF ALLERGY IN CHILDREN .1. ASSOCIATION WITH VIRUS-INFECTIONS
DEVELOPMENT OF ALLERGY IN CHILDREN .1. ASSOCIATION WITH VIRUS-INFECTIONS
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DOI：
10.1016/0091-6749(79)90106-4
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发表时间：
1979-01-01
影响因子：
14.2
通讯作者：
MILLS, J
中科院分区：
文献类型：
--
作者：
FRICK, OL;GERMAN, DF;MILLS, J
出生在过敏家庭的孩子，如果父母双方都过敏，在5岁前发生过敏的风险很高。为了观察致敏过程中可能的外部因素，对13名儿童进行了前瞻性研究，在1-4年的时间里，每隔3-6个月进行一系列临床和免疫学观察。这些儿童（11名）现在临床过敏；我有哮喘。通过RAST（放射过敏原吸收试验）、抗原诱导的白细胞组胺释放、淋巴细胞生成和血清免疫球蛋白E升高，观察11例患儿过敏性致敏的免疫学证据。上呼吸道感染（URI）发生在11例过敏儿童发生过敏致敏前1-2个月。在11例URI患儿中的10例中，针对病毒(副流感、RSV（呼吸道合胞病毒）、CMV（巨细胞包涵病毒）的补体固定抗体在首次证实免疫过敏致敏的相同血液样本中增加。某些病毒可能导致过敏致敏过程。
Children born into allergic families, with 2 allergic parents, are at high risk of developing allergy within the first 5 yr of life. To observe possible external factors in the sensitization process, a prospective study of 13 such children was done, where serial clinical and immunologic observations were made at 3-6 mo. intervals over 1-4 yr. The children (11) are now clinically allergic; 5 have asthma. Immunologic evidence for allergic sensitization was observed in the 11 children by RAST [radioallergosorbent test], antigen-induced leukocyte histamine release, lymphoblastogenesis and rise in serum Ig[immunoglobulin]E. Upper respiratory infections (URI) occurred in the 11 allergic children 1-2 mo. prior to the onset of allergic sensitization. In 10 of the 11 URI children, complement-fixing antibodies to viruses (parainfluenza, RSV [respiratory syncytial virus], CMV [cytomegalic inclusion virus]) increased in the same blood samples where immunologic allergic sensitization was first evidenced. Certain viruses may contribute to the allergic sensitization process.