One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation.
One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation.
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电子烟（eC）可能并不完全是良性的。缺乏使用各种加热源和功率设置单次急性暴露于eC蒸汽对肺损伤影响的数据。本研究的目的是确定急性暴露于用不同加热元件和功率水平加热的eC蒸汽是否会引起肺和心脏的炎症变化。将大鼠暴露于纯空气或接受单次暴露于eC蒸气4小时。该装置使用不锈钢（SS）或镍铬合金（NC）加热元件，随机分为低或高雾化功率（45与70 W）。大鼠在暴露后48小时内被安乐死。eC组在支气管腔、胸膜附近和肺泡腔内显示炎性细胞积聚。与空气组相比，暴露于eC组的大鼠肺实质中每个视野的炎性细胞数量显著更大。有显着较高的炎症基因表达的变化，在动物的肺部分配到70 W的功率。我们观察到使用燃烧线圈产生的eC蒸汽是有毒的，可引起急性呼吸窘迫和心肌炎。总之，在没有维生素E油或尼古丁的情况下，暴露于eC蒸汽4小时，显著增加了肺部炎症。在暴露于使用SS和NC加热元件在高或低功率下产生的蒸汽后观察到影响。带有燃烧线圈的器械产生的蒸汽会对心脏和肺产生负面影响。
Electronic cigarettes (eC) may not be entirely benign. There is a lack of data on the effect of a single acute exposure of eC vapor using various heating sources and power settings upon lung injury. The purpose of this study was to determine if an acute exposure with eC vapor heated with different heating elements and power levels induced inflammatory changes in the lungs and heart. Rats were exposed to pure air or received a single, 4-h exposure to eC vapor. The devices used either a stainless steel (SS) or nichrome (NC) heating element randomized to a low or high atomization power (45 versus 70 W). Rats were euthanized within 48 h of exposure. The eC groups showed accumulation of inflammatory cells in bronchial lumen, near the pleura, and within the alveolar spaces. The numbers of inflammatory cells per field in the lung parenchyma were significantly greater in the rats exposed to eC groups vs. the air group. There were significantly higher inflammatory gene expression changes in the lungs of animals assigned to 70 W power. We observed that eC vapor generated using burnt coils were toxic and could cause acute respiratory distress and myocarditis. In conclusion, one 4-h exposure to eC vapor, in the absence of vitamin E oil or nicotine, significantly increased lung inflammation. Effects were seen after exposures to vapor generated using SS and NC heating elements at either high or low power. Vapor from devices with burnt coils can negatively affect the heart and lung.