Safety of 6-Hz primed low-frequency rTMS in stroke
Safety of 6-Hz primed low-frequency rTMS in stroke
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DOI：
10.1177/1545968307305458
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发表时间：
2008-03-01
影响因子：
4.2
通讯作者：
Pascual-Leone, Alvaro
中科院分区：
文献类型：
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作者：
Carey, James R.;Evans, Chad D.;Pascual-Leone, Alvaro
背景。抑制对侧运动皮层的活动可能促进中风后功能的恢复。此外，已知的低频重复经颅磁刺激（rTMS）的抑制作用可以通过6hz启动刺激来增强和延长。目标。作者探讨了6赫兹启动低频rTMS在10例缺血性脑卒中患者中的安全性。方法。启动包括10分钟的6 hz rTMS，以90%的静息运动阈值，以2组/分钟，5秒/组，间隔25秒的方式施加于对侧半球。低频rTMS包括在静息运动阈值的90%下进行额外10分钟的1 hz rTMS，不间断。采用美国国立卫生研究院卒中量表（NIHSS）、韦氏成人智力量表第三版（WAIS-III）、霍普金斯语言学习测试修订版（HVLT-R）、贝克抑郁量表第二版（BDI-II）、手指运动跟踪测试和个人自我评估来评估可能的不良反应。在第一天进行前测、治疗和后测，在接下来的5个工作日进行随访。结果。没有癫痫发作，NIHSS、WAIS-TII或BDI-II评分没有受损。HVLT-R发生短暂性损伤。短暂的疲劳是常见的。偶尔报告出现头痛、颈部疼痛、睡眠增加、睡眠减少、恶心和焦虑。结论。由于没有主要的不良反应，作者得出结论，该治疗对本研究中的个体是安全的，现在有必要进一步研究6赫兹启动低频rTMS系列治疗的有效性和安全性。
Background. Suppression of activity in the contralesional motor cortex may promote recovery of function after stroke. Furthermore, the known depressant effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) can be increased and prolonged by preceding it with 6-Hz priming stimulation. Objective. The authors explored the safety of 6-Hz primed low-frequency rTMS in 10 patients with ischemic stroke. Methods. Priming consisted of 10 minutes of 6-Hz rTMS applied to the contralesional hemisphere at 90% of resting motor threshold delivered in 2 trains/min with 5 s/train and 25-second intervals between trains. Low-frequency rTMS consisted of an additional 10 minutes of 1-Hz rTMS at 90% of resting motor threshold without interruption. Possible adverse effects were assessed with the National Institutes of Health Stroke Scale (NIHSS), the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the Hopkins Verbal Learning Test-Revised (HVLT-R), the Beck Depression Inventory-Second Edition (BDI-II), a finger movement tracking test, and individual self-assessments. Pretest, treatment, and posttest occurred on the first day with follow-up tests on the next 5 weekdays. Results. There were no seizures and no impairment of NIHSS, WAIS-TII, or BDI-II scores. Transient impairment occurred on the HVLT-R. Transient tiredness was common. Occasional reports of headache, neck pain, increased sleep, reduced sleep, nausea, and anxiety occurred. Conclusion. Because there were no major adverse effects, the authors concluded that the treatment was safe for the individuals in this study and that further investigation is now warranted to examine efficacy and safety of serial treatments of 6-Hz primed low-frequency rTMS.