Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle
Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle
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DOI：
10.1007/978-90-481-9713-2_6
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发表时间：
2011-01-01
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影响因子：
--
通讯作者：
Delbono, Osvaldo
中科院分区：
文献类型：
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作者：
Delbono, Osvaldo
衰老与力量下降有关，这可能导致老年人日常生活活动能力受损。神经肌肉系统的功能和结构下降已被认为是这种损伤和丧失独立性的原因，但与年龄相关的力量损失大于哺乳动物（包括人类）肌肉质量的损失，并且其潜在机制仅部分了解。本章重点介绍骨骼肌兴奋-收缩解偶联（ECU），外部钙依赖性骨骼肌收缩，JP-45和其他最近发现的肌肉T-小管-肌浆网连接（三联体）分子在兴奋-收缩偶联（ECC）中的作用，骨骼肌的神经影响，以及营养因子特别是胰岛素样生长因子-I（IGF-I）在运动单位和神经肌肉接头随衰老的结构和功能改变中的作用。更好地了解参与肌肉ECC和神经/肌肉相互作用的三联蛋白及其调节，将导致更合理的干预措施，以延缓或预防随着年龄的增长而出现的肌无力。
Aging is associated with decreasing strength that can lead to impaired performance of daily living activities in the elderly. Functional and structural decline in the neuromuscular system has been recognized as a cause of this impairment and loss of independence, but the age-related loss of strength is greater than the loss of muscle mass in mammals, including humans, and the underlying mechanisms remain only partially understood. This chapter focuses on skeletal muscle excitation-contraction uncoupling (ECU), external calcium-dependent skeletal muscle contraction, the role of JP-45 and other recently discovered molecules of the muscle T-tubule-sarcoplasmic reticulum junction (triad) in excitation-contraction coupling (ECC), the neural influence of skeletal muscle, and the role of trophic factors particularly insulin-like growth factor-I (IGF-I) in structural and functional modifications of the motor unit and the neuromuscular junction with aging. A better understanding of the triad proteins involved in muscle ECC and nerve/muscle interactions and their regulation will lead to more rational interventions to delay or prevent muscle weakness with aging.