Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis.
Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis.
复制标题
血浆同型半胱氨酸水平升高作为动脉粥样硬化危险因素的重要性。
DOI：
10.1016/0003-4975(94)90522-3
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Porter,JM
中科院分区：
文献类型：
--
作者：
Masser,PA;TaylorJr,LM;Porter,JM
动脉粥样硬化是西方世界导致死亡和残疾的主要原因，而血浆氨基酸同型半胱氨酸水平升高可能是导致动脉粥样硬化的一个重要危险因素。本文综述了同型半胱氨酸的生化特征，以及其在动脉粥样硬化中的病理作用的历史、实验室和临床证据。研究了降低升高的同型半胱氨酸水平的可能治疗方法以及治疗对动脉粥样硬化的可能影响。
Atherosclerosis is a leading cause of death and disability in the Western world, and an important risk factor for it may be an elevated level of the plasma amino acid homocysteine. The biochemical characteristics of homocysteine, along with historical, laboratory, and clinical evidence for its pathologic role in atherosclerosis, are reviewed. Possible therapies for reducing elevated homocysteine levels and the possible impact of therapy in atherosclerosis are examined.