Pontomedullary raphe neurons: intracellular responses to central and peripheral electrical stimulation.
Pontomedullary raphe neurons: intracellular responses to central and peripheral electrical stimulation.
复制标题
桥髓中缝神经元：对中枢和外周电刺激的细胞内反应。
DOI：
10.1016/0006-8993(84)91449-5
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Foote,WE
中科院分区：
文献类型：
--
作者：
Maciewicz,R;Sandrew,BB;Phipps,BS;Poletti,CE;Foote,WE
在氯醛糖麻醉的猫上，用细胞内方法研究了中缝桥延髓神经元对电刺激延髓网状结构（MRF）和中脑腹侧导水管周围灰质（PAG）的反应。单一的PAG在trophilar核水平的冲击刺激诱发短潜伏期，单突触兴奋性突触后电位（EPSP）在逆向鉴定中缝脊神经元。刺激两侧延髓网状结构可产生类似的大EPSP。绝大多数中缝核脊髓神经元对坐骨神经休克有反应，大多数对牙髓或前爪休克也有反应;这些反应总是双侧的。不能从脊髓逆向侵入的细胞的反应与中缝核神经元的反应相似，但变化更大。细胞内注射辣根过氧化物酶的电生理特征的细胞显示，大多数记录是由大型和中型中缝神经元。这些研究结果进行了讨论的背景下，潜在的作用脑桥延髓中缝神经元的伤害性感受。
The responses of pontomedullary raphe neurons to electrical stimulation of the medullary reticular formation (MRF) and the mesencephalic ventral periaqueductal gray region (PAG) were studied using intracellular methods in chloralose-anesthetized cats. Single shock stimulation of PAG at the level of the trochlear nucleus evoked short latency, monosynaptic excitatory postsynaptic potentials (EPSPs) in antidromically identified raphe-spinal neurons. Similar large EPSPs were produced by medullary reticular stimulation of either side. The large majority of raphe-spinal neurons responded to sciatic nerve shock, and most responded to tooth pulp or forepaw shock as well; these responses were always bilateral. The responses of cells that could not be antidromically invaded from spinal cord were similar to those of raphe-spinal neurons, but tended to be more variable. Intracellular injection of horseradish peroxidase into electrophysiologically characterized cells revealed that most recordings were made from large and medium sized raphe neurons. These findings are discussed in the context of a potential role for pontomedullary raphe neurons in nociception.