Perinatal stress, fatigue, depressive symptoms, and immune modulation in late pregnancy and one month postpartum.
Perinatal stress, fatigue, depressive symptoms, and immune modulation in late pregnancy and one month postpartum.
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DOI：
10.1155/2014/652630
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Pickler, R H
中科院分区：
文献类型：
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作者：
Cheng, C Y;Pickler, R H
压力和疲劳以及抑郁症是孕妇和产后妇女常见的抱怨。这些症状可能与免疫调节有关。然而，很少有研究检验这些关系。本研究的目的是检查压力、疲劳、抑郁和细胞因子之间的关系，作为产前和产后妇女免疫调节的标志。妇女在怀孕后期和产后 4-6 周再次填写问卷并提供血液样本。分析血液中的细胞因子作为免疫调节的措施。压力、疲劳和抑郁程度处于中等偏高水平，其中产后疲劳和抑郁程度较高，但产前时期压力较高。与产前相比，产后几种细胞因子的水平有所增加。产前的压力和抑郁有关，产后的压力、抑郁和疲劳也有关。虽然这两个时期的各种细胞因子彼此相关，但只有压力与 MIP-1beta 相关，MIP-1beta 是一种对分娩过程可能很重要的细胞因子。需要更多的研究，特别是纵向和介入研究，以增加我们对孕产妇痛苦的病因、模式、症状、因素和管理的了解。为高危母亲寻找可靠的生物标志物仍然是一个优先事项。
Stress and fatigue are common complaints of pregnant and postpartum women as is depression. These symptoms may be related to immunomodulation. However, few studies have examined these relationships. The aim of this study was to examine the relationships among stress, fatigue, depression, and cytokines as markers of immune modulation in prenatal and postpartum women. Women completed questionnaires and gave blood samples during late pregnancy and again at 4-6 weeks postpartum. Blood was analyzed for cytokines as measures of immune modulation. Stress, fatigue, and depression were experienced at moderately high levels, with higher levels of fatigue and depression in the postpartum but higher stress in the prenatal period. Levels of several cytokines were increased in the postpartum over the prenatal period. Stress and depression were related in the prenatal period and stress, depression, and fatigue were related in the postpartum. While various cytokines were related to each other in both periods, only stress was related to MIP-1beta, a cytokine that may be important for childbirth processes. More studies, especially longitudinal and interventional studies, are needed to increase our knowledge about etiology, patterns, symptoms, factors, and management of maternal distress. The search for reliable biomarkers for at-risk mothers remains a priority.