Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status
Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status
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DOI：
10.1021/jf800930s
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发表时间：
2008-08-27
影响因子：
6.1
通讯作者：
Konishi, Tetsuya
中科院分区：
文献类型：
--
作者：
Rahman, M. Mamunur;Ichiyanagi, Takashi;Konishi, Tetsuya
有强有力的证据表明，氧化应激参与了帕金森病和阿尔茨海默病等神经退行性疾病的病因学。此外，情绪压力对中枢神经系统的影响在体内平衡中起着至关重要的作用。采用胡须切割模型研究花青素对脑氧化应激的保护作用。在小鼠中，这种治疗会导致心理或情绪困扰，从而导致组织氧化应激。为了研究花青素的体内抗氧化活性，将越橘提取物（一种花青素混合物）给小鼠口服（100毫克/千克体重）7天，然后通过剪掉它们的胡须来评估心理压力。晶须的去除增加了大脑、心脏、肾脏和肝脏中蛋白质羰基的形成和脂质过氧化。此外，氧化标记物的水平显示出大脑中的区域差异。与此同时，中脑和大脑皮层的多巴胺神经递质水平也发生了变化。口服花青素在大脑中也很活跃，可以抑制应激小鼠的大脑氧化应激和多巴胺异常。花青素治疗的这些作用表明它们可能有助于治疗与氧化应激相关的脑部疾病。
There is strong evidence that oxidative stress participates in the etiology of neurodegenerative diseases such as Parkinson's, and Alzheimer's diseases. Moreover, emotional stress effects in the central nervous system play a vital role in homeostasis. The protective effect of anthocyanins on the cerebral oxidative stress was studied using the whiskers cut model. In mice, such treatment causes psychological or emotional distress leading to oxidative stress in tissues. To investigate the in vivo antioxidant activity of anthocyanins, an extract of Vaccinium myrtillis L., an anthocyanin mixture, was orally administered (100 mg/kg of body weight.) to mice for 7 days, and then psychological stress was assessed by cutting off their whiskers. Whisker removal increased both protein carbonyl formation and lipid peroxidation in the brain, heart, kidney, and liver. Further, the levels of oxidative markers showed regional differences in the brain. Concomitantly, dopamine neurotransmitter levels were altered in both the midbrain and the brain cortex. Orally administered anthocyanins were also active in the brain, suppressing stress-induced cerebral oxidative stress and dopamine abnormalities in distressed mice. These effects of anthocyanin treatment suggest their possible usefulness for the treatment of cerebral disorders related to oxidative stress.