Synthesis and Evaluation of 4-Acyl-2-thiazolylhydrazone Derivatives for Anti-Toxoplasma Efficacy in Vitro
Synthesis and Evaluation of 4-Acyl-2-thiazolylhydrazone Derivatives for Anti-Toxoplasma Efficacy in Vitro
复制标题
DOI：
10.1021/jm9005862
复制
发表时间：
2009-08-13
影响因子：
7.3
通讯作者：
Jones-Brando, Lorraine
中科院分区：
文献类型：
--
作者：
Chimenti, Franco;Bizzarri, Bruna;Jones-Brando, Lorraine
合成了一系列新的4-酰基-2-噻唑肼类化合物，并对其体外抗弓形虫活性进行了筛选。我们评估了寄生虫的生长抑制和细胞毒性，抑制了复制。抑制寄生虫对宿主细胞的入侵。生物学实验结果表明，某些物质对体外培养的弓形虫速殖子具有抗增殖作用。
A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication. and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.