Regulation of body size and behavioral state of C-elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase
Regulation of body size and behavioral state of C-elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase
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DOI：
10.1016/s0896-6273(02)01093-0
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发表时间：
2002-12-19
期刊：
影响因子：
16.2
通讯作者：
McIntire, SL
中科院分区：
文献类型：
--
作者：
Fujiwara, M;Sengupta, P;McIntire, SL
高等生物的生长和行为依赖于神经系统对感官刺激的准确感知和整合。我们表明，在C。线虫导致动物生长异常和替代行为状态的表达异常。我们的分析表明，感觉神经元调节神经或神经内分泌功能，调节身体生长和行为状态。我们确定了可能需要这些功能下游的感觉输入的基因。在这里，我们将这些基因之一描述为egl-4，我们显示其编码cGMP依赖性蛋白激酶。我们证明了这种cGMP依赖性激酶在C.线虫调节多种发育和行为过程，包括动物的协调生长和特定行为状态的表达。
The growth and behavior of higher organisms depend on the accurate perception and integration of sensory stimuli by the nervous system. We show that defects in sensory perception in C. elegans result in abnormalities in the growth of the animal and in the expression of alternative behavioral states. Our analysis suggests that sensory neurons modulate neural or neuroendocrine functions, regulating both bodily growth and behavioral state. We identify genes likely to be required for these functions downstream of sensory inputs. Here, we characterize one of these genes as egl-4, which we show encodes a cGMP-dependent protein kinase. We demonstrate that this cGMP-dependent kinase functions in neurons of C. elegans to regulate multiple developmental and behavioral processes including the orchestrated growth of the animal and the expression of particular behavioral states.