Relationship between natural killer activity and development of hepatocellular carcinoma in patients with cirrhosis of the liver.
Relationship between natural killer activity and development of hepatocellular carcinoma in patients with cirrhosis of the liver.
复制标题
肝硬化患者自然杀伤活性与肝癌发生的关系。
DOI：
--
复制
发表时间：
1987
影响因子：
2.4
通讯作者：
K. Kanai
中科院分区：
文献类型：
--
作者：
T. Nakajima;N. Mizushima;K. Kanai
本文对50例非酒精性肝硬化（LC）患者外周血淋巴细胞（PBL）自然杀伤（NK）活性进行了前瞻性研究，以探讨NK活性受损与肝细胞癌（HCC）发生的关系。根据研究开始时患者的NK活性将患者分为两组，即NK活性正常的A组（n = 21）和NK活性降低的B组（n = 29）。NK活性连续测定每个患者长达40个月。在观察期间，12例患者（4至36个月）发生了HCC。在发生HCC的患者中，2例属于A组（9.5%），10例属于B组（34.5%）。这些结果表明，在LC患者的NK活性下降是增加他们的发展为HCC的风险的关键因素之一，和NK活性的系列测定是重要的，在预测肝癌的发生在以下LC患者的临床过程。
Natural killer (NK) activities of peripheral blood lymphocytes (PBL) in 50 patients with non-alcoholic liver cirrhosis (LC) were prospectively studied in order to clarify the relation between the development of hepatocellular carcinoma (HCC) and impaired NK activities. Patients were divided into two groups according to their NK activities at the beginning of the study, namely, Group A with normal NK activity (n = 21) and Group B with decreased NK activity (n = 29). NK activities were serially determined in each patient for up to 40 months. During the observation period, the occurrence of HCC was identified in 12 patients (four to 36 months). Of the patients who developed HCCs, two belonged to Group A (9.5%) and 10 belonged to Group B (34.5%). These results suggest decreased NK activity in LC patients to be one of the critical factors increasing their risk of developing HCC, and serial determinations of NK activities to be important in predicting the occurrence of HCCs in following the clinical course of LC patients.