Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia
Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia
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表观扩散系数和垂体大腺瘤：肿瘤异型性的术前评估
DOI：
10.1007/s11102-016-0759-5
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发表时间：
2017
期刊：
影响因子：
3.8
通讯作者：
C. Glastonbury
中科院分区：
文献类型：
--
作者：
B. Tamrazi;M. Pekmezci;Mariam Aboian;T. Tihan;C. Glastonbury
理由和目的垂体大腺瘤主要是良性颅内肿瘤，可局部侵袭邻近结构。在病理学文献中已经确定了攻击行为的生物标志物，包括增殖标志物mb -1。在放射学文献中，弥散加权成像和低ADC值提供了脑肿瘤侵袭行为的相似标记。本研究的目的是确定垂体大腺瘤中ADC和MIB-1之间是否存在相关性。材料与方法回顾性分析垂体大腺瘤的扩散成像及免疫组织化学特征。测定ADC比和标本Ki-67 （MIB-1）指数。采用归一化ADC值和MIB-1指数的线性回归分析对这些参数进行比较。结果17例患者有可用的ADC图谱和MIB-1指标。11例患者经影像学及术中观察证实有局部侵犯。侵袭组平均ADC比为0.68，平均MIB-1指数为2.21%。无创组平均ADC比为1.05，平均MIB-1指数为0.9%。归一化ADC值与MIB-1的线性回归分析显示呈负相关，线性斜率显著不同于零（p = 0.003，相关系数为0.77，r方= 0.59）。结论：低ADC值与mb -1有很强的相关性，表明弥散成像可能是非典型增殖性腺瘤的生物标志物，最终可能影响手术入路和术后处理。
Rationale and objectivesPituitary macroadenomas are predominantly benign intracranial neoplasms that can be locally aggressive with invasion of adjacent structures. Biomarkers of aggressive behavior have been identified in the pathology literature, including the proliferative marker MIB-1. In the radiology literature, diffusion weighted imaging and low ADC values provide similar markers of aggressive behavior in brain tumors. The purpose of this study was to determine if there is a correlation between ADC and MIB-1 in pituitary macroadenomas.Materials and methodsA retrospective review of diffusion imaging and immunohistochemical characteristics of pituitary macroadenomas was performed. The ADC ratio and specimen Ki-67 (MIB-1) indices were measured. Linear regression analysis of normalized ADC values and MIB-1 indices was used to compare these parameters.ResultsThere were 17 patients with available ADC maps and MIB-1 indices. Local invasion was confirmed by imaging and intraoperative visualization in 11 patients. The mean ADC ratio for the invasive group was 0.68, with a mean MIB-1 index of 2.21 %. In the noninvasive group, the mean ADC ratio was 1.05, with a mean MIB-1 index of 0.9 %. Linear regression analysis of normalized ADC values versus MIB-1 demonstrates a negative correlation, with a linear slope significantly different from zero (p = 0.003, correlation coefficient of 0.77, and r squared = 0.59).ConclusionWe determine a strong correlation of low ADC values and MIB-1, demonstrating the potential of diffusion imaging as a possible biomarker for atypical, proliferative adenomas, which may ultimately affect the surgical approach and postoperative management.
通过药理学伴侣拯救致病突变人胰高血糖素受体。
影响因子：
3.5
作者：
Yu,Run;Chen,Chun-Rong;Liu,Xiaohong;Kodra,JanosT
通讯作者：
Kodra,JanosT