Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples.
Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples.
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DOI：
10.1016/j.neuron.2016.10.020
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发表时间：
2016-12-07
期刊：
影响因子：
16.2
通讯作者：
Dupret D
中科院分区：
文献类型：
--
作者：
van de Ven GM;Trouche S;McNamara CG;Allen K;Dupret D
恢复代表记忆信息的神经元组件的能力被认为需要在睡眠/休息期间通过离线重新激活来巩固它们。为了测试这一点，我们检测了在探索空间环境的过程中，小鼠海马体中反复的神经元共同激活形成的细胞组装模式。我们发现，组装模式的恢复代表了一种新的，但不是熟悉的环境，与它们的离线重新激活相关，并受到尖锐波纹振荡的闭环光遗传破坏的损害。此外，我们发现，只有在对新位置编码过程中表达逐渐增强的组装模式恢复时，才需要重新激活。组装模式的上下文相关恢复，其表达在空间编码的最初几分钟后没有增强，并不依赖于重新激活。这表明，海马体可以同时容纳不同的空间表征，这些表征在编码动态和对离线重新激活进行巩固的依赖方面存在显著差异。多神经元共激活在海马区形成空间编码的组装模式离线重新激活新的组装模式与未来的恢复相关SWR沉默损害了一个新的但不是熟悉的地方的模式的巩固代表一个新的地方的“早期稳定的”模式不需要重新激活van de Ven等人。识别由重复的多个神经元共激活形成的海马细胞组装模式，并表明只有那些代表新位置并且在第一次表达过程中逐渐增强的模式才需要重新激活SWR才能进行上下文相关的恢复。
The ability to reinstate neuronal assemblies representing mnemonic information is thought to require their consolidation through offline reactivation during sleep/rest. To test this, we detected cell assembly patterns formed by repeated neuronal co-activations in the mouse hippocampus during exploration of spatial environments. We found that the reinstatement of assembly patterns representing a novel, but not a familiar, environment correlated with their offline reactivation and was impaired by closed-loop optogenetic disruption of sharp wave-ripple oscillations. Moreover, we discovered that reactivation was only required for the reinstatement of assembly patterns whose expression was gradually strengthened during encoding of a novel place. The context-dependent reinstatement of assembly patterns whose expression did not gain in strength beyond the first few minutes of spatial encoding was not dependent on reactivation. This demonstrates that the hippocampus can hold concurrent representations of space that markedly differ in their encoding dynamics and their dependence on offline reactivation for consolidation. Multi-neuron co-activations form space-coding assembly patterns in the hippocampus Offline reactivation of new assembly patterns correlates with future reinstatement SWR silencing impairs consolidation of patterns of a novel, but not a familiar, place “Early stabilized” patterns representing a novel place do not require reactivation van de Ven et al. identify hippocampal cell assembly patterns formed by repeated multi-neuron co-activations and show that only those patterns that represent a novel place and that were gradually strengthened during their first expression require SWR reactivation for their context-dependent reinstatement.