Functional reorganization of the rat motor cortex following motor skill learning
Functional reorganization of the rat motor cortex following motor skill learning
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DOI：
10.1152/jn.1998.80.6.3321
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发表时间：
1998-12-01
影响因子：
2.5
通讯作者：
Nudo, RJ
中科院分区：
文献类型：
--
作者：
Kleim, JA;Barbay, S;Nudo, RJ
成年大鼠被分配到一个熟练或不熟练的达到条件（SRC和URC，分别）。SRC动物在熟练的伸手任务上训练10天，而URC动物在简单的压杆任务上训练。训练后，微电极刺激被用来获得运动皮层内的前肢和后肢表征的高分辨率地图。与URC动物相比，SRC动物表现出手腕和手指代表的平均面积显着增加，但减少肘/肩代表的前肢尾侧区域内。没有组间差异的面积代表性被发现在后肢或喙前肢地区。这些结果表明，运动技能学习与啮齿动物运动皮层内的运动表征的重组有关。
Adult rats were allocated to either a skilled or unskilled reaching condition (SRC and URC, respectively). SRC animals were trained for 10 days on a skilled reaching task while URC animals were trained on a simple bar pressing task. After training, microelectrode stimulation was used to derive high resolution maps of the forelimb and hindlimb representations within the motor cortex. In comparison with URC animals, SRC animals exhibited a significant increase in mean area of the wrist and digit representations but a decrease in elbow/shoulder representation within the caudal forelimb area. No between-group differences in areal representation were found in either the hindlimb-or rostral forelimb areas. These results demonstrate that motor skill learning is associated with a reorganization of movement representations within the rodent motor cortex.