Development of Blood Extraction System for Health Monitoring System
Development of Blood Extraction System for Health Monitoring System
复制标题
DOI：
10.1117/12.522237
复制
发表时间：
2004-03
影响因子：
2.8
通讯作者：
K. Tsuchiya;Naoyuki Nakanishi;Y. Uetsuji;E. Nakamachi
中科院分区：
文献类型：
--
作者：
K. Tsuchiya;Naoyuki Nakanishi;Y. Uetsuji;E. Nakamachi
我们专注于研究开发用于血糖自我监测 (SMBG) 的紧凑型人体血液采样装置。 SMBG 包括：(1) 使用形状记忆合金 (SMA) 致动器迫使微针穿过皮肤的压痕系统； (2)使用双压电晶片型压电微致动器抽取血液的微电泵系统； (3)生物传感器，使用葡萄糖氧化酶(GOx)等酶来检测和评估提取的血液中的葡萄糖量。采用溅射沉积方法制备了与雌性蚊子阴唇尺寸相同（外径60μm，内径25μm）的钛微针。该装置的机械设计基于蚊子的血液采样机制。血液抽取系统运转良好。我们测量了主要部件的性能：外径 100 μm 的微针的压痕载荷为 0.1 N。泵系统对全血的提取速度约为 2 μl/min。这与蚊子所达到的效果类似。
We focus on research to develop a compact human blood sampling device used for the Self Monitoring of Blood Glucose (SMBG). The SMBG comprises: (1) an indentation system using a shape memory alloy (SMA) actuator to force a microneedle through the skin; (2) a micro electrical pumping system to extract blood using a bimorph type piezoelectric microactuator; (3) a biosensor using an enzyme such as glucose oxidase (GOx) to detect and evaluate the amount of glucose in extracted blood. A titanium microneedle the same size as a female mosquito's labium (60 μm outer diameter, 25 μm inner diameter) was produced by the sputter deposition method. The mechanical design of the device was based upon the mosquito's blood sampling mechanism. The blood extraction system worked well. We measured the performance of the principal components: the indentation load for a microneedle of external diameter 100 μm was found to be 0.1 N. The pumping system has an extraction speed of about 2 μl/min for whole blood. This is similar to that achieved by the mosquito.