Behavioral versus genetic correlates of lipoproteins and adiposity in identical twins discordant for exercise.
Behavioral versus genetic correlates of lipoproteins and adiposity in identical twins discordant for exercise.
复制标题
运动不一致的同卵双胞胎中脂蛋白和肥胖的行为与遗传相关性。
DOI：
10.1161/circulationaha.105.534578
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发表时间：
2005
期刊：
影响因子：
37.8
通讯作者：
Krauss,RonaldM
中科院分区：
文献类型：
--
作者：
Williams,PaulT;Blanche,PatriciaJ;Krauss,RonaldM
研究背景：高强度运动和久坐的同卵双胞胎之间的脂蛋白和体重差异被用来(1)在控制基因型的情况下估计训练的影响，(2)在不同生活方式下估计遗传一致性（即相似性）。方法与结果：在全国范围内招募35对MZ双胞胎（男25对，女10对），这些双胞胎在剧烈运动方面不一致（男双胞胎跑步距离≥40公里，女双胞胎跑步距离≥32公里）。活跃的双胞胎平均（平均±SD）跑63.0±20.4公里/周，而最久坐的双胞胎平均跑7.0±13.5公里/周。运动组体重指数（差值±SE，±2.12±0.57 kg/m2，P=0.0007）显著降低，高密度脂蛋白胆固醇（0.14±0.04 mmol/L，P=0.004）、高密度脂蛋白l2（2.71±1.04 U，P=0.01）、载脂蛋白A-I（0.10±0.03 g/L，P=0.004）显著升高。尽管生活方式存在差异，但当对性别进行调整时，不一致的MZ双胞胎在HDL胆固醇（r=0.69）、apoA-I （r=0.58）和HDL2（r=0.67）方面的相关性显著（P<0.01）。体重指数与MZ - twin无显著相关（r=0.17）。活跃的双胞胎中没有一个超重的双胞胎本身超重。结论：行为（剧烈运动）可以减少基因对体重指数的影响。相反，基因（或共同环境）对高密度脂蛋白胆固醇和高密度脂蛋白亚类的影响很大，即使存在极端的行为差异。适度肥胖可能有更大的个人控制，而低高密度脂蛋白胆固醇可能在很大程度上是预先确定的，并且通过剧烈运动治疗效果较差。
Background—Lipoprotein and weight differences between vigorously active and sedentary monozygotic (MZ) twins were used to (1) estimate the effects of training while controlling for genotype and (2) estimate genetic concordance (ie, similarity) in the presence of divergent lifestyles.Methods and Results—Thirty-five pairs of MZ twins (25 male, 10 female) were recruited nationally who were discordant for vigorous exercise (running distances differed by ≥40 km in male and ≥32 km in female twins). The active twins ran an average (mean±SD) of 63.0±20.4 km/wk, whereas the mostly sedentary twins averaged 7.0±13.5 km/wk. The active twins had significantly lower body mass index (difference±SE, −2.12±0.57 kg/m2,P=0.0007) and significantly higher HDL cholesterol (0.14±0.04 mmol/L,P=0.004), HDL2(2.71±1.04 U,P=0.01), and apolipoprotein (apo) A-I (0.10±0.03 g/L,P=0.004). Despite the difference in lifestyle, when adjusted for sex, the correlations between the discordant MZ twin pairs were significant (P<0.01) for HDL cholesterol (r=0.69), apoA-I (r=0.58), and HDL2(r=0.67). There was no significant MZ twin correlation for body mass index (r=0.17). None of the active twins having an overweight twin were themselves overweight.Conclusions—Behavior (vigorous exercise) may reduce genetic influences on body mass index. In contrast, genetics (or shared environment) substantially influences HDL cholesterol and HDL subclasses, even in the presence of extreme behavioral differences. There may be greater individual control over moderate degrees of obesity, whereas low HDL cholesterol may be largely predetermined and less effectively treated by vigorous exercise.