Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress.
Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress.
复制标题
DOI：
10.1042/bst20150273
复制
发表时间：
2016-04-15
影响因子：
3.9
通讯作者：
Baird B
中科院分区：
文献类型：
--
作者：
Holowka D;Wilkes M;Stefan C;Baird B
肥大细胞上高亲和力受体FcεRI与IgE结合后，其钙离子动员是免疫变态反应的核心。这种交联引起的刺激的酪氨酸磷酸化激活了钙池操作的Ca 2+进入，导致依赖于Rho家族GTPases和磷酸肌醇合成的持续Ca 2+振荡。耦合内质网（ER）Ca2+传感器，STIM 1，钙离子选择性通道，Orai 1，是由这些元素的调节，并依赖于膜组织，在质膜和ER。线粒体也有助于调节Ca2+动员，我们描述了最近的证据表明，ER膜蛋白VAP在ER和线粒体之间的耦合在这个过程中发挥了重要作用。除了颗粒胞吐，在这些细胞中的Ca2+动员也有助于刺激向外贩运的再循环内体和抗原刺激的趋化性，它是由原生动物寄生虫入侵的病理调节。
Ca2+ mobilization in response to crosslinking of IgE bound to its high affinity receptor, FcεRI, on mast cells is central to immune allergic responses. Stimulated tyrosine phosphorylation caused by this crosslinking activates store-operated Ca2+ entry that results in sustained Ca2+ oscillations dependent on Rho family GTPases and phosphoinositide synthesis. Coupling of the endoplasmic reticulum (ER) Ca2+ sensor, STIM1, to the Ca2+-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER. Mitochondria also contribute to the regulation of Ca2+ mobilization, and we describe recent evidence that the ER membrane protein VAP plays a significant role in the coupling between ER and mitochondria in this process. In addition to granule exocytosis, Ca2+ mobilization in these cells also contributes to stimulated outward trafficking of recycling endosomes and to antigen-stimulated chemotaxis, and it is pathologically regulated by protozoan parasitic invasion.