Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
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DOI：
10.3109/15622971003611319
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发表时间：
2010-09-01
影响因子：
3.1
通讯作者：
Gennarelli, Massimo
中科院分区：
文献类型：
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作者：
Bocchio-Chiavetto, Luisella;Bagnardi, Vincenzo;Gennarelli, Massimo
目标。重度抑郁症（MD）患者血清和血浆中神经营养因子水平下降的研究支持了BDNF信号传导的改变。我们进行了一项重复性研究，并对MD患者血清和血浆BDNF水平的研究进行了两项荟萃分析。方法。样本由489例患者/483例血清荟萃分析对照组和161例患者/211例血浆水平荟萃分析对照组组成。我们还进行了亚组分析，以检查MD中BDNF水平的下降是否受性别的影响。结果。在重复研究中，我们发现MD患者血清BDNF水平下降（P < 0.01），并证明其下调了成熟形式的神经营养因子（mBDNF）。血浆BDNF水平无显著差异。荟萃分析显示，MD患者血清BDNF （P < 0.0001）和血浆BDNF水平均降低（P = 0.02）。男性和女性对血清BDNF的影响大小无差异（P = 0.18）。结论。总之，我们的研究结果提供了外周BDNF在MD中改变的证据，并支持了进一步研究的理论基础，旨在确定该疾病的鉴别诊断和个性化治疗的生物标志物。
Objectives. Alterations of BDNF signalling in major depression (MD) are supported by studies demonstrating decreased levels of the neurotrophin serum and plasma content in MD patients. We conducted a replication study and we performed two meta-analyses on studies analysing serum and plasma BDNF levels in MD patients. Methods. The samples were composed by 489 patients/483 controls for the meta-analysis on serum and by 161 patients/211 controls for that on plasma levels. We performed also subgroup analyses to examine whether the decrease in BDNF levels in MD was influenced by gender. Results. In the replication study we found decreased serum BDNF levels in MD patients (P < 0.01) and we demonstrated that is down-regulated the mature form of the neurotrophin (mBDNF). No significant difference was evidenced for plasma BDNF levels. The meta-analyses showed a reduction of both BDNF serum (P < 0.0001) and plasma levels (P = 0.02) in MD. No difference in the effect size on serum BDNF was observed between males and females (P = 0.18). Conclusions. In conclusion, our results provide evidence of peripheral BDNF alteration in MD and support the rationale for further investigation aiming to the identification of biomarkers for differential diagnosis and personalization of therapies in this disorder.