Hyperpolarized 3He MR for Sensitive Imaging of Ventilation Function and Treatment Efficiency in Young Cystic Fibrosis Patients with Normal Lung Function
Hyperpolarized 3He MR for Sensitive Imaging of Ventilation Function and Treatment Efficiency in Young Cystic Fibrosis Patients with Normal Lung Function
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DOI：
10.1148/radiol.09090039
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发表时间：
2010-04-01
期刊：
影响因子：
19.7
通讯作者：
Reix, Philippe
中科院分区：
文献类型：
--
作者：
Bannier, Elise;Cieslar, Katarzyna;Reix, Philippe
目的：评估超极化氦 3 (He-3) 磁共振 (MR) 成像检测肺量测定结果正常（1 秒平均用力呼气量 [FEV1]，112% +/- 14.5 [标准差]）的年轻囊性纤维化 (CF) 患者外周气道阻塞的敏感性，并观察单次胸部物理治疗 (CPT) 疗程的即时效果，从而比较两种图像量化技术。 材料和方法：经当地研究伦理委员会批准后，10 名肺量测定结果正常的儿科 CF 患者（年龄范围，8-16 岁）纳入本研究。在 CPT 20 分钟之前和之后，使用 1.5-T MR 装置进行肺活量测定，然后进行质子和超极化 3 He 三维肺部成像。对每张图像的通气缺陷数量 (VDI) 和通气肺分数 (VF)（定义为通气肺容量除以总肺容量的比率）进行量化。结果：尽管肺活量正常，但所有患者均发现通气缺陷（平均 VDI，5.1 +/- 1.9；平均整体 VF，78.5% +/- 12.3；平均外周 VF，75.5% +/- 17.1）结果。 CPT 后，观察到通气缺陷分布的不同变化，但平均 VDI 和 VF 没有显着变化（平均 VDI，5.1 +/- 1.1；平均整体 VF，83.5% +/- 12.2；平均外周 VF，80.3% +/- 12.2）。 FEV1 和 VDI (rho = -0.041，P = .863) 或整体 VF (rho = -0.196，P = .408) 值之间没有相关性，但外周 VF 和 VDI 相关 (rho = -0.563，P = .011)。结论：虽然肺量测定结果表明肺功能正常，但本研究中发现的患者平均 VDI (5.1) 远高于平均 VDI文献报道健康受试者中的 VDI (1.6)。单次 CPT 疗程会导致通气缺陷的分布和程度发生不同的变化。 (C) 北美放射学会，2010
Purpose:To assess the sensitivity of hyperpolarized helium 3 (He-3) magnetic resonance (MR) imaging for the detection of peripheral airway obstruction in younger cystic fibrosis (CF) patients showing normal spirometric results (mean forced expiratory volume in 1 second [FEV1], 112% +/- 14.5 [standard deviation]) and to observe the immediate effects of a single chest physical therapy (CPT) session, thereby comparing two image quantification techniques.Materials and Methods:Ten pediatric CF patients (age range, 8-16 years) with normal spirometric results were included in this study after approval from the local research ethics committee. Spirometry followed by proton and hyperpolarized 3 He three-dimensional lung imaging were performed with a 1.5-T MR unit before and after 20 minutes of CPT. The number of ventilation defects per image (VDI) and the ventilated lung fraction (VF), defined as the ratio of ventilated lung volume divided by total lung volume, were quantified.Results:Ventilation defects were found in all patients (mean VDI, 5.1 +/- 1.9; mean global VF, 78.5% +/- 12.3; and mean peripheral VF, 75.5% +/- 17.1) despite normal spirometric results. After CPT, disparate changes in the distribution of ventilation defects were observed but the average VDI and VF did not change significantly (mean VDI, 5.1 +/- 1.1; mean global VF, 83.5% +/- 12.2; and mean peripheral VF, 80.3% +/- 12.2). There was no correlation between FEV1 and VDI (rho = -0.041, P = .863) or global VF (rho = -0.196, P = .408) values but peripheral VF and VDI were correlated (rho = -0.563, P = .011).Conclusion:Although spirometric results indicate normal lung function, the mean VDI in patients (5.1) found in this study is well above the VDI in healthy subjects (1.6) reported in the literature. A single CPT session induces disparate changes in the distribution and extent of ventilation defects. (C) RSNA, 2010