Classical conditioning of motor responses: What is the learning mechanism?
Classical conditioning of motor responses: What is the learning mechanism?
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DOI：
10.1016/j.neunet.2013.03.013
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发表时间：
2013-11-01
期刊：
影响因子：
7.8
通讯作者：
Johansson, Fredrik
中科院分区：
文献类型：
--
作者：
Hesslow, Germund;Jirenhed, Dan-Anders;Johansson, Fredrik
根据一个广泛持有的假设，小脑运动学习的主要机制，如眨眼条件反射，是平行纤维到浦肯野细胞突触的长期抑制（LTD）。在这里，我们回顾了一些最近的生理证据，从浦肯野细胞记录在空调与空调模型的影响。我们认为，这些数据提出了四个主要的挑战有限公司假设的条件。(i)LTD不能解释浦肯野细胞放电的暂停，而浦肯野细胞放电被认为是驱动条件性眨眼的原因。(ii)有利于LTD的时间条件与眨眼条件不匹配。(iii)有限责任公司不能很容易地说明适应性的条件反应的时间。(iv)这些数据表明，平行纤维浦肯野细胞突触学习浦肯野细胞CR后不受抑制。代谢型谷氨酸受体的基础上的模型进行了讨论，发现是不兼容的记录数据。(C)2013爱思唯尔有限公司保留所有权利。
According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data. (C) 2013 Elsevier Ltd. All rights reserved.