Well-differentiated extraskeletal osteosarcoma - Report of 2 cases, 1 with dedifferentiation
Well-differentiated extraskeletal osteosarcoma - Report of 2 cases, 1 with dedifferentiation
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DOI：
10.1016/j.humpath.2005.01.023
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发表时间：
2005-04-01
期刊：
影响因子：
3.3
通讯作者：
Steiner, GC
中科院分区：
文献类型：
--
作者：
Abramovici, LC;Hytiroglou, P;Steiner, GC
Extraskeletal osteosarcoma (ESOS) is a rare soft tissue sarcoma, typically characterized by high-grade histological features and a grave prognosis. However, 4 cases of well-differentiated ESOS with a better prognosis have been documented in the literature within the last 40 years. We report 2 additional cases, I with multicentric presentation and dedifferentiation, and we emphasize the histological features that are useful in distinguishing this lesion from other soft tissue tumors. Well-differentiated ESOS seems to represent a rare but distinct low-grade variant of ESOS. The limited published experience suggests that although the biologic behavior of this tumor is better than that of classical ESOS, there are cases with progression to a higher grade, leading eventually to final demise. (c) 2005 Elsevier Inc. All rights reserved.
