Salivary diagnostics: enhancing disease detection and making medicine better
Salivary diagnostics: enhancing disease detection and making medicine better
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DOI：
10.1111/j.1600-0579.2007.00477.x
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发表时间：
2008-02-01
影响因子：
2.4
通讯作者：
Wong, David T.
中科院分区：
文献类型：
--
作者：
Segal, Alik;Wong, David T.
无创监测健康状况、疾病的发生和发展以及治疗结果是医疗服务和健康研究中最理想的目标。实现这一目标有三个必要条件：1.非侵入性的生物样本采集方法。与健康或疾病相关的特定生物标志物。一个快速识别生物标志物的技术平台。由国家牙科和颅面研究所(NIDCR)推动的一项倡议制定了一项路线图，通过使用口腔液作为诊断介质来检查健康和疾病状况，以实现这一目标。这是连接最先进的唾液生物传感器和疾病识别唾液生物标记物在诊断应用中的理想机会。口服液，通常被称为“身体的镜子”，是健康和疾病监测的完美媒介。翻译应用和机会是巨大的。这篇综述介绍了唾液作为一种可靠的临床诊断液的翻译价值和这种使用的科学原理。
To monitor health status, disease onset and progression, and treatment outcome non-invasively is a most desirable goal in the health care delivery and health research. There are three prerequisites necessary to reach this goal:1. A non-invasive method for collecting biological samples.2. Specific biomarkers associated with health or disease.3. A technology platform to rapidly discriminate the biomarkers.An initiative catalysed by the National Institute of Dental and Craniofacial Research (NIDCR) has created a roadmap to achieve this goal through the use of oral fluids as the diagnostic medium to scrutinize the health and disease status. This is an ideal opportunity to bridge state-of-the-art saliva-based biosensors and disease-discriminatory salivary biomarkers in diagnostic applications. Oral fluid, often called the 'mirror of the body', is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous. This review presents the translational value of saliva as a credible clinical diagnostic fluid and the scientific rationale for such use.