At-home sample collection is an effective strategy for diagnosis and management of symptomatic and asymptomatic SARS-CoV-2 carriers.
At-home sample collection is an effective strategy for diagnosis and management of symptomatic and asymptomatic SARS-CoV-2 carriers.
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DOI：
10.1186/s12879-022-07377-4
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发表时间：
2022-05-09
影响因子：
3.7
通讯作者：
Bauer, Timothy A.
中科院分区：
文献类型：
--
作者：
Humphreys, Devon P.;Gavin, Kathleen M.;Olds, Kaylan M.;Bonaca, Marc P.;Bauer, Timothy A.
SARS-CoV-2诊断检测的可及性和无症状传播对遏制和预防COVID-19的社区流行构成了重大挑战。在家采集样本进行分子检测为疾病控制和预防提供了方便有效的解决方案。这是一项回顾性、横断面、病例对照研究。我们的主要目的是确定SARS-CoV-2在无症状与有症状个体中的流行率和相对风险，使用家庭样本采集试剂盒进行诊断。参与者包括来自美国各地的成年人，他们在2020年5月至2021年9月期间完成了COVID-19家庭收集套件。主要测量包括自我报告的症状和在家自我采集的前鼻拭子RT-PCR检测SARS-CoV-2结果。该分析包括282，831人的数据。在此期间，与全国平均水平相比，在家测试者的SARS-CoV-2总体患病率较低（3.28%对7.68%）。与有症状者相比，无症状者的阳性检测结果风险较低（风险比：0.080，95% CI，0.078-0.082）。然而，在所有SARS-CoV-2阳性检测中，48.75%来自在检测时没有报告症状的个人。我们的结论是，在家中采集样本是一种可行的选择，对于改善检测的可及性、发现无症状病例和遏制可预防的COVID-19传播来说，这是一种潜在的重要策略。
Diagnostic testing accessibility and asymptomatic transmission of SARS-CoV-2 present major challenges for curbing and preventing community prevalence of COVID-19. At-home sample collection for molecular testing provides a convenient and effective solution for disease containment and prevention. This is a retrospective, cross-sectional, case-control study. Our primary aim was to determine the prevalence and relative risk of SARS-CoV-2 among asymptomatic versus symptomatic individuals using at-home sample collection kits for diagnosis. Participants included adults from across the United States who completed a COVID-19 Home Collection kit between May 2020 and September 2021. Main measurements included self-reported symptoms and at-home self-collected anterior nasal swab RT-PCR test results for SARS-CoV-2. Data from 282,831 individuals were included in this analysis. The overall SARS-CoV-2 prevalence of at-home test takers was low compared to national averages during this period (3.28% vs. 7.68%). Those reporting no symptoms were at lower risk of positive test results compared to those with symptoms (risk ratio: 0.080, 95% CI, 0.078–0.082). However, of all positive SARS-CoV-2 tests, 48.75% were from individuals reporting no symptoms at the time of testing. We conclude that at-home sample collection is a viable option and potentially important strategy for improving access to testing, detecting asymptomatic cases, and curbing preventable transmission of COVID-19.
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影响因子：
9.3
作者：
Hellewell J;Russell TW;SAFER Investigators and Field Study Team;Crick COVID-19 Consortium;CMMID COVID-19 working group;Beale R;Kelly G;Houlihan C;Nastouli E;Kucharski AJ
通讯作者：
Kucharski AJ
DOI：
10.1016/s1473-3099(20)30833-1
发表时间：
2021-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Ng OT;Marimuthu K;Koh V;Pang J;Linn KZ;Sun J;De Wang L;Chia WN;Tiu C;Chan M;Ling LM;Vasoo S;Abdad MY;Chia PY;Lee TH;Lin RJ;Sadarangani SP;Chen MI;Said Z;Kurupatham L;Pung R;Wang LF;Cook AR;Leo YS;Lee VJ
通讯作者：
Lee VJ
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ
影响因子：
4.8
作者：
Ricci S;Lodi L;Citera F;Nieddu F;Moriondo M;Guarnieri V;Giovannini M;Indolfi G;Resti M;Zanobini A;Azzari C
通讯作者：
Azzari C
DOI：
10.12890/2021_002463
发表时间：
2021-01-01
影响因子：
--
作者：
De Carvalho, Joao Gabriel;Hvozdara, Kateryna
通讯作者：
Hvozdara, Kateryna