Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity.
Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity.
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DOI：
10.3390/vaccines9020075
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发表时间：
2021-01-21
期刊：
影响因子：
7.8
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Li Z;Zhao Y;Li Y;Chen X
流感对全球公共卫生构成巨大威胁。流感疫苗是控制流感的最有效和最具成本效益的手段。目前的流感疫苗主要诱导针对高度可变的血凝素球状头的中和抗体，缺乏交叉保护。疫苗佐剂已被批准用于增强老年人季节性流感疫苗的效力和节省流感疫苗剂量。临床研究发现，MF59和AS03佐剂流感疫苗可诱导针对非疫苗病毒株的交叉保护性免疫。除了MF59和AS03佐剂之外，实验佐剂，例如Toll样受体激动剂、基于皂苷的佐剂、基于霍乱毒素和热不稳定肠毒素的粘膜佐剂和物理佐剂，也能够扩大流感疫苗诱导的针对非疫苗株的免疫应答。本文重点介绍了在临床前和临床研究中能够辅助现有流感疫苗诱导交叉保护性免疫的各种佐剂。还介绍了许可的MF59和AS03佐剂诱导交叉保护性免疫的机制。疫苗佐剂具有很大的前景，可以作为流感疫苗的佐剂，诱导交叉保护性免疫。
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of hemagglutinin and lack cross-protection. Vaccine adjuvants have been approved to enhance seasonal influenza vaccine efficacy in the elderly and spare influenza vaccine doses. Clinical studies found that MF59 and AS03-adjuvanted influenza vaccines could induce cross-protective immunity against non-vaccine viral strains. In addition to MF59 and AS03 adjuvants, experimental adjuvants, such as Toll-like receptor agonists, saponin-based adjuvants, cholera toxin and heat-labile enterotoxin-based mucosal adjuvants, and physical adjuvants, are also able to broaden influenza vaccine-induced immune responses against non-vaccine strains. This review focuses on introducing the various types of adjuvants capable of assisting current influenza vaccines to induce cross-protective immunity in preclinical and clinical studies. Mechanisms of licensed MF59 and AS03 adjuvants to induce cross-protective immunity are also introduced. Vaccine adjuvants hold a great promise to adjuvant influenza vaccines to induce cross-protective immunity.
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