TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway
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TRIM52：一种核 TRIM 蛋白，正向调节核因子-κ B 信号通路
DOI：
10.1016/j.molimm.2017.01.003
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发表时间：
2017-02-01
影响因子：
3.6
通讯作者：
Qian, Ping
中科院分区：
文献类型：
--
作者：
Fan, Wenchun;Liu, Tingting;Qian, Ping
新的证据表明 TRIM 家族蛋白在调节 NF-kappa B 信号通路中发挥着至关重要的作用。 TRIM52 是一种新型非经典抗病毒 TRIM 基因，具有独特的扩展 RING 结构域。有关 TRIM52 生物学功能的信息有限。在此，我们证明 TRIM52 参与 NF-kappa B 激活。我们发现 TRIM52 过表达特异性激活 NF-kappa B 信号。 TRIM52过表达可显着诱导TNFα和IL-6表达。我们还发现 TRIM52 的 RING 结构域对于激活 NF-κ B 信号至关重要。进一步研究表明TRIM52过表达并不影响I kappa B α和磷酸化p65蛋白的蛋白水平。我们发现促炎细胞因子TNFα和IL-6可以诱导TRIM52表达。总体而言，这些数据表明 TRIM52 是 NF-kappa B 通路的正调节因子。 (C) 2017 Elsevier Ltd. 保留所有权利。
Emerging evidence suggests that TRIM family proteins play a crucial role in regulating the NF-kappa B signaling pathway. TRIM52 is a novel noncanonical antiviral TRIM gene with a unique expanded RING domain. Information on the biological function of TRIM52 is limited. Herein, we demonstrated TRIM52 involvement in NF-kappa B activation. We found that TRIM52 overexpression specifically activated the NF-kappa B signal. TRIM52 overexpression can significantly induce TNF alpha and IL-6 expression. We also found that the RING domain of TRIM52 was essential for its activation of the NF-kappa B signal. Further study showed that TRIM52 overexpression did not affect the protein level of I kappa B alpha and phosphorylated p65 protein. We found that the pro-inflammatory cytokines TNF alpha and IL-6 could induce TRIM52 expression. Overall, these data suggested that TRIM52 was a positive regulator of the NF-kappa B pathway. (C) 2017 Elsevier Ltd. All rights reserved.