An SHR-SCR module specifies legume cortical cell fate to enable nodulation
An SHR-SCR module specifies legume cortical cell fate to enable nodulation
复制标题
SHR™SCR 模块指定豆类皮质细胞的命运以实现结瘤
DOI：
10.1038/s41586-020-3016-z
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发表时间：
2020-12-09
期刊：
影响因子：
64.8
通讯作者：
Wang, Ertao
中科院分区：
文献类型：
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作者：
Dong, Wentao;Zhu, Yayun;Wang, Ertao
豆科植物与其他植物不同，它具有与固氮根瘤菌建立共生关系的能力。据推测，豆科植物根皮层细胞的独特性质使根瘤菌共生的最初建立成为可能（1-3）。在这里，我们表明，一个SHORTROOT-SCARECROW（SHR-SCR）干细胞程序在皮质细胞的豆科植物蒺藜苜蓿指定其独特的命运。调控元件驱动SCR的皮质表达，并且中柱表达的SHR蛋白在M的皮质细胞中积累。truncatula而不是拟南芥。皮层SHR-SCR网络在豆科植物中是保守的，响应根瘤菌信号，并启动豆科植物特异性皮层细胞分裂，用于从头结瘤器官发生和根瘤菌的适应。豆类植物中SHR和SCR的异位激活足以诱导根皮层细胞分裂。我们的工作表明，收购皮质SHR-SCR模块使细胞分裂耦合根瘤菌感染豆类。我们认为，这一事件是核心的根瘤菌内共生的进化。
Legumes, unlike other plants, have the ability to establish symbiosis with nitrogen-fixing rhizobia. It has been theorized that a unique property of legume root cortical cells enabled the initial establishment of rhizobial symbiosis(1-3). Here we show that a SHORTROOT-SCARECROW (SHR-SCR) stem cell program in cortical cells of the legume Medicago truncatula specifies their distinct fate. Regulatory elements drive the cortical expression of SCR, and stele-expressed SHR protein accumulates in cortical cells of M. truncatula but not Arabidopsis thaliana. The cortical SHR-SCR network is conserved across legume species, responds to rhizobial signals, and initiates legume-specific cortical cell division for de novo nodule organogenesis and accommodation of rhizobia. Ectopic activation of SHR and SCR in legumes is sufficient to induce root cortical cell division. Our work suggests that acquisition of the cortical SHR-SCR module enabled cell division coupled to rhizobial infection in legumes. We propose that this event was central to the evolution of rhizobial endosymbiosis.