Functions of the hydrophilic channels in protonmotive cytochrome c oxidase
Functions of the hydrophilic channels in protonmotive cytochrome c oxidase
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DOI：
10.1098/rsif.2013.0183
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发表时间：
2013-09-06
影响因子：
3.9
通讯作者：
Marechal, Amandine
中科院分区：
文献类型：
--
作者：
Rich, Peter R.;Marechal, Amandine
讨论了电子传递膜蛋白中亲水通道的结构和功能。可以传导质子的质子通道和不导电但可以响应于埋入功能中心引入电荷变化而介电极化的介电通道之间存在区别。结合这些想法对 A1 型细胞色素 c 氧化酶中发现的 K、D 和 H 通道的功能进行了回顾。探讨了介电通道对功能的可能控制及其与质子通道的进化关系。
The structures and functions of hydrophilic channels in electron-transferring membrane proteins are discussed. A distinction is made between proton channels that can conduct protons and dielectric channels that are non-conducting but can dielectrically polarize in response to the introduction of charge changes in buried functional centres. Functions of the K, D and H channels found in A1-type cytochrome c oxidases are reviewed in relation to these ideas. Possible control of function by dielectric channels and their evolutionary relation to proton channels is explored.