Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: A cross-sectional study
Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: A cross-sectional study
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DOI：
10.1016/j.biopsych.2005.08.031
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发表时间：
2006-04-01
影响因子：
10.6
通讯作者：
Peterson, BS
中科院分区：
文献类型：
--
作者：
Blumberg, HP;Krystal, JH;Peterson, BS
背景：神经影像资料显示，双相情感障碍(BD)在青春期和青春期进展过程中，腹侧前额叶皮质(VPFC)功能受损。然而，BD中VPFC形态异常的发展轨迹尚不清楚。方法：对37例BD患者(青少年14例，青年10例，老年人13例)和56例健康对照(HC)的VPFC进行了成像研究。用高分辨率结构磁共振成像(MRI)测量VPFC的灰质和白质体积。我们使用混合模型，重复测量分析来检查不同年龄组的VPFC体积，同时对总脑体积进行协变。结果：VPFC容量随年龄增长而下降(p<0.05)。
Background: Neuroimaging data suggest that deficits in ventral prefrontal cortex (VPFC) function in bipolar disorder (BD) progress during adolescence and young adulthood. However, the developmental trajectory of VPFC morphological abnormalities in BD is unknown. This study investigated potential age-dependent volume abnormalities in VPFC in BD.Methods: Thirty-seven individuals diagnosed with BD I (14 adolescents, 10 young adults and 13 older adults) and 56 healthy comparison subjects (HC) participated in imaging. Gray and white matter volumes of VPFC were measured using high-resolution structural magnetic resonance imaging (MRI). We used a mixed model, repeated measures analysis to examine VPFC volumes across age groups while co-varying for total brain volume. Potential effects of illness features including rapid-cycling and medication were explored.Results: VPFC volumes declined with age (p