Tissue microenvironments within functional cortical subdivisions adjacent to focal stroke
Tissue microenvironments within functional cortical subdivisions adjacent to focal stroke
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DOI：
10.1097/01.wcb.0000084252.20114.be
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发表时间：
2003-09-01
影响因子：
6.3
通讯作者：
Carmichael, ST
中科院分区：
文献类型：
--
作者：
Katsman, D;Zheng, J;Carmichael, ST
中风会产生一个完整的细胞死亡区域，以及部分损伤、损伤和胶质细胞增生的区域。这些受损区域对梗塞核心和备用神经元回路的空间关系尚未确定。皮质卒中模型是在躯体感觉皮质的功能亚群中发展起来的。梗死面积、细胞凋亡区、DNA氧化损伤、热休克蛋白诱导和反应性胶质细胞增生症的亚型通过躯体感觉体感图被精确定位、量化和相互关联。识别出三种组织微环境：局部缺血损伤区、热休克蛋白诱导区和弥散性胶质细胞增殖区。这三个区域涉及的皮质离子逐渐变得更远，每个区域都比梗死核心大。部分缺血损伤区代表了一个重叠的区域，包括凋亡细胞死亡、氧化性DNA损伤、突触连接丢失和局部反应性胶质增生。分布的胶质增殖区占据了躯体感觉皮质的不同功能区。卒中引起的组织重组远大于卒中部位本身。邻近的组织微环境是具有明显反应性细胞信号的部位，可能是局灶性卒中后急性细胞死亡和神经元延迟可塑性过程的纽带。
Stroke produces a region of complete cell death and areas of partial damage, injury, and gliosis. The spatial relationship of these regions of damage to the infarct core and within spared neuronal circuits has not been identified. A Model of cortical stroke was developed within functional subsets of the somatosensory cortex. Infarct size, regions of apoptosis, oxidative DNA damage, heat shock protein induction, and subtypes of reactive gliosis were precisely mapped with the somatosensory body map, quantified, and interrelated. Three tissue microenvironments were recognized: zones of partial ischemic damage, heat shock protein induction, and distributed gliosis. These three zones involved progressively more distant cortical re-ions, each larger than the infarct core. The zone of partial ischemic damage represents an overlap region of apoptotic cell death, oxidative DNA damage, loss of synaptic connections, and local reactive gliosis. The zone of distributed gliosis Occupies distinct functional areas of the somatosensory cortex. The tissue reorganization induced by stroke is much larger than the stroke site itself. Adjacent tissue microenvironments are sites of distinct reactive cellular signalingg and may serve as a link between the processes of acute cell death and delayed neuronal plasticity after focal stroke.