Intensity of platelet β3 integrin in patients with hemorrhagic fever with renal syndrome and its correlation with disease severity
Intensity of platelet β3 integrin in patients with hemorrhagic fever with renal syndrome and its correlation with disease severity
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DOI：
10.1089/vim.2007.0098
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发表时间：
2008-06-01
期刊：
影响因子：
2.2
通讯作者：
Zhang, Ni
中科院分区：
文献类型：
--
作者：
Liu, Zhengwen;Gao, Maicang;Zhang, Ni
beta(3) 整合素已被确定为汉坦病毒的细胞受体，汉坦病毒会导致肾综合征出血热 (HFRS)。为了研究血小板膜β3整合素（CD61）强度与疾病严重程度之间的关系，通过流式细胞术测定了HFRS患者的CD61阳性血小板百分比和血小板CD61的平均荧光强度（MFI）。 HFRS 患者的 CD61 强度水平显着高于对照组，并且与疾病的临床阶段相关。少尿期CD61强度与血小板计数、血清白蛋白呈负相关，与白细胞计数、血尿素氮、血清肌酐、丙氨酸转氨酶水平呈正相关。结果表明，HFRS 患者血小板 CD61 强度水平升高，且与临床分期和疾病严重程度相关，HFRS 患者血小板 β(3) 整合素强度可能指示疾病严重程度。
beta(3) Integrin has been identified as a cellular receptor for Hantaan virus, which causes hemorrhagic fever with renal syndrome (HFRS). To investigate the relationship between intensity of the platelet membrane beta 3 integrin (CD61) and disease severity, the percentage of CD61-positive platelets and the mean fluorescence intensities (MFI) of platelet CD61 were determined in patients with HFRS by flow cytometry. The intensity levels of CD61 in patients with HFRS were significantly higher than those in the controls and correlated with the clinical phases of the disease. The CD61 intensity at the oliguric phase was inversely correlated with platelet count and serum albumin, and positively correlated with white blood cell count, blood urea nitrogen, serum creatinine, and alanine aminotransferase levels. The results suggest that the intensity levels of platelet CD61 were elevated and associated with clinical phases and disease severity in patients with HFRS, and the intensity of platelet beta(3) integrin in patients with HFRS may be indicative of disease severity.