Treatment of hormone-dependent cancer with analogues of hypothalamic hormones. Experimental and clinical studies.
Treatment of hormone-dependent cancer with analogues of hypothalamic hormones. Experimental and clinical studies.
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用下丘脑激素类似物治疗激素依赖性癌症。
DOI：
10.1111/j.1749-6632.1987.tb35820.x
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发表时间：
1987
影响因子：
5.2
通讯作者：
Schally,AV
中科院分区：
文献类型：
--
作者：
Schally,AV
基于促黄体生成素释放激素（LH-RH）激动剂或生长抑素类似物的治疗内分泌依赖性或激素敏感性肿瘤的新方法似乎是有希望的。长期给予LH-RH的6-~-色氨酸（D-Trp 6）类似物和其他LH-RH激动剂后，垂体和性腺功能受到明显抑制，导致化学去势，并可能成为治疗性激素依赖性肿瘤的新方法。
A new approach to the treatment of endocrine-dependent or hormone-sensitive tumors based on agonists of luteinizing hormone-releasing hormone (LH-RH) or somatostatin analogues appears to be promising. A marked inhibition of pituitary and gonadal function that occurs after chronic administration of the 6-~-tryptophan (D-Trp6) analog of LH-RH and other LH-RH agonists’-’leads to a chemical castration and makes possible a new approach for the treatment of sex-hormone-dependent tumors.’