Simvastatin treatment increases nitrite levels in obese women: Modulation by T-786C polymorphism of eNOS
Simvastatin treatment increases nitrite levels in obese women: Modulation by T-786C polymorphism of eNOS
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DOI：
10.1016/j.niox.2013.07.005
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发表时间：
2013-09-01
影响因子：
3.9
通讯作者：
Sandrim, V. C.
中科院分区：
文献类型：
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作者：
Andrade, V. L.;Sertorio, J. T. C.;Sandrim, V. C.
目的和主题：有证据表明肥胖症中一氧化氮 (NO) 受损。他汀类药物具有独立于降低胆固醇的多效作用，包括增加 eNOS 表达和抗氧化作用。我们评估了辛伐他汀治疗 45 天对无合并症（高血压、糖尿病和血脂异常）的肥胖女性循环亚硝酸盐（NO 标记物）和 TBARS-MDA 水平的影响。此外，我们验证了携带位于eNOS中的T-786C多态性C变体的肥胖女性与TT基因型相比，治疗后亚硝酸盐水平是否可能升高。结果：辛伐他汀治疗后，虽然血浆亚硝酸盐水平增加了42%（P = 0.0008），但TBARS-MDA水平降低了58%（P = 0.0069）。我们观察到两组基因型（TT 与 TC + CC）的亚硝酸盐水平均增加；然而，与 TT 中的 44% 相比，C 等位基因携带者的增加为 60%。 结论：我们的结果表明，接受辛伐他汀治疗的肥胖女性的亚硝酸盐水平得到恢复，这是由 T-786C 多态性调节的。 (C) 2013 Elsevier Inc. 保留所有权利。
Objective and Subjects: Evidence indicates an impairment of nitric oxide (NO) in obesity. Statins present pleiotropic effects independently of cholesterol-lowering, including increasing of eNOS expression and antioxidant effects. We evaluated the effects of simvastatin treatment at 45 days on circulating nitrite (NO marker) and TBARS-MDA levels in obese women without comorbidities (hypertension, diabetes and dyslipidemia). Moreover, we verified whether obese women carrying the C variant of T-786C polymorphism located in eNOS may have increased levels of nitrite after treatment compared to TT genotype.Results: After simvastatin treatment, while the plasma nitrite levels increased 42% (P = 0.0008), the TBARS-MDA levels reduced 58% (P = 0.0069). We observed increased levels of nitrite in both groups of genotypes (TT vs. TC + CC); however, rise in C-allele carriers was 60% comparing with 44% in TT.Conclusion: Our results demonstrated a restoration of nitrite levels in obese women treated with simvastatin, which is modulated by T-786C polymorphism. (C) 2013 Elsevier Inc. All rights reserved.