Standardised comparison of glucose intolerance in West African-origin populations of rural and urban Cameroon, Jamaica, and Caribbean migrants to Britain
Standardised comparison of glucose intolerance in West African-origin populations of rural and urban Cameroon, Jamaica, and Caribbean migrants to Britain
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DOI：
10.2337/diacare.22.3.434
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发表时间：
1999-03-01
期刊：
影响因子：
16.2
通讯作者：
Wilks, R
中科院分区：
文献类型：
--
作者：
Mbanya, JCN;Cruickshank, JK;Wilks, R
目的-比较遗传相似的非洲裔人口在喀麦隆和牙买加和Britain.Research设计和方法葡萄糖耐受不良的患病率-研究对象是从农村和城市喀麦隆或牙买加，或加勒比移民，主要是牙买加人，生活在英国曼彻斯特。抽样基础包括喀麦隆25-74岁成年人的地方普查、牙买加具有统计代表性的地区和曼彻斯特的人口登记。非洲-加勒比族裔要求该族裔的三个祖父母：糖尿病是由世界卫生组织（WHO）1985年标准使用75克口服葡萄糖耐量试验定义的（2小时大于或等于11.1 mmol/l或低血糖治疗）和新的美国糖尿病协会标准（空腹血糖大于或等于7.0 mmol/l或低血糖治疗）。结果-对于男性来说，喀麦隆城市和曼彻斯特的平均BMI最大在喀麦隆和牙买加的城市，女性的这一比例同样很高，曼彻斯特最高（27-28公斤/平方米）。根据世卫组织标准，喀麦隆农村地区的年龄标准化糖尿病患病率为0.8%，城市地区为2.0%，牙买加为8.5%，曼彻斯特为14.6%，男女之间没有差异（男性：1.1%、1.0%、6.5%、15.3%，女性：0.5%、2.8%、10.6%、14.0%）。所有趋势检验P < 0.001，葡萄糖耐量受损在牙买加更为常见。结论-葡萄糖耐量不耐受从喀麦隆到牙买加和英国的转变表明，环境决定了这些具有相似遗传起源的人群中的糖尿病患病率。
OBJECTIVE - To compare the prevalence of glucose intolerance in genetically similar African-origin populations within Cameroon and from Jamaica and Britain.RESEARCH DESIGN AND METHODS - Subjects studied were from rural and urban Cameroon or from Jamaica, or were Caribbean migrants, mainly Jamaican, living in Manchester, England. Sampling bases included a local census of adults aged 25-74 years in Cameroon, districts statistically representative in Jamaica, and population registers in Manchester. African-Caribbean ethnicity required three grandparents of this ethnicity: Diabetes was defined by the World Health Organization (WHO) 1985 criteria using a 75-g oral glucose tolerance test (2-h greater than or equal to 11.1 mmol/l or hypoglycemic treatment) and by the new American Diabetes Association criteria (fasting glucose greater than or equal to 7.0 mmol/l or hypoglycemic treatment).RESULTS - For men, mean BMIs were greatest in urban Cameroon and Manchester (25-27 kg/m(2)); in women, these were similarly high in urban Cameroon and Jamaica and highest in Manchester (27-28 kg/m(2)). The age-standardized diabetes prevalence using WHO criteria was 0.8% in rural Cameroon, 2.0% in urban Cameroon, 8.5% in Jamaica, and 14.6% in Manchester, with no difference between sexes (men: 1.1%, 1.0%, 6.5%, 15.3%, women: 0.5%, 2.8%, 10.6%, 14.0%). all tests for trend P < 0.001, Impaired glucose tolerance was more frequent in Jamaica.CONCLUSIONS - The transition in glucose intolerance from Cameroon to Jamaica and Britain suggests that environment determines diabetes prevalence in these populations of similar genetic origin.