A role for hepatocyte growth factor/scatter factor in regulating normal and neoplastic cells of reproductive tissues.
A role for hepatocyte growth factor/scatter factor in regulating normal and neoplastic cells of reproductive tissues.
复制标题
肝细胞生长因子/分散因子在调节生殖组织正常和肿瘤细胞中的作用。
DOI：
10.1016/s1071-5576(97)00111-1
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Peluso,JJ
中科院分区：
文献类型：
--
作者：
Lail-Trecker,M;Gulati,R;Peluso,JJ
Objective:To review data regarding the expression, function, and signal transduction pathways associated with hepatocyte growth factor/scatter factor (HGF/SF) as related to normal and neoplastic cells of reproductive tissues.Methods:Studies involving HGF/SF were reviewed and the data were summarized.Results:Hepatocyte growth factor/scatter factor is generally expressed within the stromal components of the testis, prostate, placenta, mammary gland, uterine endometrium, and ovary. The receptor for HGF/SF, c-met, is expressed in the epithelial cells of these tissues. Ligand activation of c-met results in its autotyrosine phosphorylation and the subsequent stimulation of numerous signal transduction pathways. Which pathways are activated determine in part the effect that HGF/SF has on a specific tissue. Hepatocyte growth factor/scatter factor can promote a variety of biologic responses including mitosis, motogenesis (ie, cell movement), differentiation, and apoptosis. In addition, both HGF/SF and c-met continue to be expressed during the neoplastic transformation of cells from these reproductive tissues.Conclusion:Hapatocyte growth factor/scatter factor plays an important role in regulating the physiologic function of several reproductive tissues and may also be involved in the oncogenesis of cells within these tissues.
