Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis
Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis
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DOI：
10.1007/s10865-016-9770-6
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发表时间：
2016-12-01
影响因子：
3.1
通讯作者：
Kalichman, Seth C.
中科院分区：
文献类型：
--
作者：
Finitsis, David J.;Pellowski, Jennifer A.;Kalichman, Seth C.
艾滋病毒的有效治疗取决于保持足够的抗逆转录病毒治疗依从性。为了更好地应对艾滋病毒大流行，需要对服药依从性进行准确、具有成本效益的衡量。视觉模拟标尺(VAS)似乎是一种简单易用的依从性衡量标准，但目前关于其使用的文献褒贬不一。这一荟萃分析(1)描述了VAS与药物依从性和病毒载量的其他衡量标准的一致性；以及(2)考察了研究方法如何缓和VAS-病毒载量关系的报道强度。通过电子和手工方式进行文献检索，共有20项研究纳入本研究。VAS与大多数其他依从性指标显示出很大的相关性，而与病毒载量的相关性较小。更严格的方法学质量显著改善了VAS-病毒载量效应的大小。最后，我们对VAS在临床实践和研究设计中的应用提出了优化建议。
Effective treatment of HIV hinges upon maintaining adequate antiretroviral therapy adherence. Accurate, cost-effective measurement of medication adherence is needed to best respond to the HIV pandemic. The visual analogue scale (VAS) appears to be a simple and easy to use measure of adherence but the current literature on its use is mixed. This meta-analysis (1) describes VAS concordance with other measures of medication adherence and viral load; and (2) examines how research methods moderate the reported strength of the VAS-viral load relationship. Literature searches were conducted electronically and by hand with a total of 20 studies included in the present study. The VAS showed large strength associations with most other measures of adherence and a smaller association with viral load. More rigorous methodological quality significantly improved the VAS-viral load effect size. We conclude with optimization recommendations for VAS use in clinical practice and research design.