Human milk anti-inflammatory component contents during acute mastitis
Human milk anti-inflammatory component contents during acute mastitis
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DOI：
10.1006/cimm.2001.1813
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发表时间：
2001-06-15
影响因子：
4.3
通讯作者：
Hair, PS
中科院分区：
文献类型：
--
作者：
Buescher, ES;Hair, PS
乳腺炎是人类哺乳期常见的并发症。我们检查了8名临床乳腺炎妇女的乳汁标本，以确定其抗炎成分的含量。与正常乳汁相比，抗氧化活性（自发性细胞色素c还原活性）、选定的促炎细胞因子（IL-6、IL-1 β）、选定的内源性细胞因子控制分子（sIL-6 R、sIL-1 RII和sTNFRI）、乳铁蛋白、Na+：K+比值以及导致sIL-1 RII从人多形核白细胞（PMN）脱落、抑制PMN聚集和抑制PMN粘附反应的乳汁生物活性均未增加。无论是消耗PAIN细胞内Ca 2+商店的生物活性，也不是那些阻止Ca 2+流入fMLP刺激的PMN显着增加乳腺炎牛奶。相比之下，TNF α、sTNFRII和IL-1 RA的水平以及导致sTNFRI从人PMN脱落的生物活性与正常乳汁相比显著增加。乳腺炎乳汁具有与正常乳汁相同的抗炎成分和特征，所选成分/活性升高，可能有助于保护哺乳期婴儿免于因喂养乳腺炎乳汁而发生临床疾病。(C)北京：科学出版社.
Mastitis is a common complication of human lactation. We examined milk specimens from eight women with clinical mastitis to determine their content of anti-inflammatory components. Antioxidant activity (spontaneous cytochrome c reducing activity), selected pro-inflammatory cytokines (IL-6, IL-1 beta), selected endogenous cytokine control molecules (sIL-6R, sIL-1RII, and sTNFRI), lactoferrin, Na+:K+ ratios, and milk bioactivities that cause shedding of sIL-1RII from human polymorphonuclear leukocytes (PMN), suppress PMN aggregation, and suppress PMN adherence responses were not increased compared to normal milks. Neither the bioactivities that deplete PAIN intracellular Ca2+ stores nor those that block Ca2+ influx into fMLP-stimulated PMN were significantly increased in mastitis milks. In contrast, levels of TNF alpha, sTNFRII, and IL-1RA and bioactivities that cause shedding of sTNFRI from human PMN were significantly increased compared to normal milks. Mastitis milk has the same anti-inflammatory components and characteristics of normal milk, with elevations in selected components/activities that may help protect the nursing infant from developing clinical illness due to feeding on mastitis milk. (C) 2001 Academic Press.