GLUCOSE BREAKDOWN IN CHICK EMBRYO CELLS INFECTED WITH INFLUENZA VIRUS
GLUCOSE BREAKDOWN IN CHICK EMBRYO CELLS INFECTED WITH INFLUENZA VIRUS
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DOI：
10.1016/0042-6822(61)90033-2
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发表时间：
1961-01-01
期刊：
影响因子：
3.7
通讯作者：
KLEMPERER, H
中科院分区：
文献类型：
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作者：
KLEMPERER, H
有氧糖酵解占鸡胚细胞摄取葡萄糖的30%。少于10%的蛋白质通过戊糖循环直接氧化。后一种途径不是核糖核酸合成的重要核糖来源。在感染后1.5小时内，当补体结合抗原首次出现时，有氧糖酵解增加50- 100%。3小时后，当血凝素出现时，葡萄糖通过戊糖循环的直接氧化增加了30- 50%。糖酵解速率受磷酸盐和磷酸受体的供应限制，三磷酸吡啶核苷酸是葡萄糖直接氧化的限速因子。感染后，由于与病毒合成相关的反应，这些物质可能会释放到细胞中。
Aerobic glycolysis accounted for 30% of the glucose taken up by chick embryo cells. Less than 10% was directly oxidized via the pentose cycle. The latter pathway was not a significant source of ribose for ribonucleic acid synthesis. Within 1.5 hours of infection, when complement-fixing antigen first appeared, aerobic glycolysis was increased 50-100%. After 3 hours, when hemagglutinin appeared, the direct oxidation of glucose via the pentose cycle increased by 30-50%. The rate of glycolysis was limited by the supply of phosphate and phosphate-acceptor; triphospho-pyridine nucleotide was a rate-limiting factor in the direct oxidation of glucose. Following infection these materials may be released in the cell as a consequence of reactions associated with virus synthesis.