Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma
Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma
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DOI：
10.1016/j.bbrc.2019.10.127
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发表时间：
2020-01-08
影响因子：
3.1
通讯作者：
Sun, Tuanqi
中科院分区：
文献类型：
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作者：
Sun, Wenyu;Wang, Yunjun;Sun, Tuanqi
含有三联基序 (TRIM) 的蛋白 14 (TRIM14) 与许多恶性肿瘤有关。目前，我们研究TRIM14是否在人甲状腺乳头状癌（PTC）中发挥作用。在此，与正常甲状腺样本相比，TRIM14 在肿瘤组织中表达上调。在 PTC 患者中，增强的 TRIM14 可以预测较短的无复发生存 (RFS) 时间。然后，我们发现在人PTC K1细胞中敲低TRIM14可抑制细胞增殖，诱导细胞凋亡并阻止裸鼠的致瘤性。相反，人PTC TPC1细胞中TRIM14的过表达促进细胞增殖，同时抑制细胞凋亡。 TRIM14 通过促进信号转导子和转录激活子 3 (STAT3) 的激活发挥其致癌活性。此外，TRIM14 与细胞因子信号传导 1 (SOCS1) 抑制剂（STAT3 激活的负调节因子）相互作用，敲低 TRIM14 会抑制 SOCS1 泛素化。总之，TRIM14可能是PTC的预后因素和癌基因，并可能是PTC干预的潜在靶点。 (C) 2019 Elsevier Inc. 保留所有权利。
Tripartite motif (TRIM)-containing protein 14 (TRIM14) is implicated in many malignancies. Presently, we studied whether TRIM14 played a role in human papillary thyroid carcinoma (PTC). Herein, TRIM14 was up-regulated in tumor tissues when compared with normal thyroid samples. Among PTC patients, enhanced TRIM14 predicted short recurrence free survival (RFS) time. Then, we found that knockdown of TRIM14 in human PTC K1 cells inhibited cell proliferation, induced cell apoptosis and prevented the tumorigenicity in nude mice. On the contrary, TRIM14 overexpression in human PTC TPC1 cells promoted cell proliferation while inhibited cell apoptosis. TRIM14 exerted its oncogenic activities via promoting the activation of signal transducer and activator of transcription 3 (STAT3). Further, TRIM14 interacted with the suppressor of cytokine-signaling-1 (SOCS1), a negative regulator of STAT3 activation, and knockdown of TRIM14 inhibited SOCS1 ubiquitination. In conclusion, TRIM14 may be a prognostic factor and oncogene in PTC, and may be a potential target for PTC intervention. (C) 2019 Elsevier Inc. All rights reserved.