Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension
Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension
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DOI：
10.1016/j.placenta.2014.05.003
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发表时间：
2014-08-01
期刊：
影响因子：
3.8
通讯作者：
Ernst, L. M.
中科院分区：
文献类型：
--
作者：
Mestan, K. K.;Check, J.;Ernst, L. M.
简介：支气管肺发育不良 (BPD) 是婴儿期最常见的慢性肺部疾病，与 BPD 相关的肺动脉高压 (PH) 是一种严重的并发症，会对儿童后期的健康产生负面影响。越来越多的证据表明，导致 BPD 和 PH 的肺损伤是由于胎儿慢性缺氧缺血所致。本研究的目的是探讨母体血管灌注不足（MVU）的胎盘病理改变是否与BPD相关，并进一步随PH的增加而增加。 方法：我们对出生的早产儿进行了为期5年的回顾性队列研究
Introduction: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of infancy, and BPD-associated pulmonary hypertension (PH) is a serious complication that can negatively impact later childhood health. There is growing evidence that lung injury leading to BPD and PH is due to chronic fetal hypoxia-ischemia. The purpose of this study was to investigate whether placental pathologic changes of maternal vascular underperfusion (MVU) are associated with BPD, and further increased with PH.Methods: We conducted a 5-year retrospective cohort study of premature infants born