Separate circuitries encode the hedonic and nutritional values of sugar.
Separate circuitries encode the hedonic and nutritional values of sugar.
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DOI：
10.1038/nn.4224
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发表时间：
2016-03
影响因子：
25
通讯作者：
de Araujo IE
中科院分区：
文献类型：
--
作者：
Tellez LA;Han W;Zhang X;Ferreira TL;Perez IO;Shammah-Lagnado SJ;van den Pol AN;de Araujo IE
糖通过味觉和进食后途径发挥其强大的强化作用。然而，目前尚不清楚甜味和营养信号是否参与了分离的大脑网络来刺激摄取。我们在小鼠身上发现，单独的基底节环路调节糖的享乐和营养作用。我们发现，在糖摄取过程中，抑制享乐值抑制了腹侧纹状体的多巴胺释放，但不抑制背侧纹状体的多巴胺释放；抑制营养价值抑制了背侧纹状体的多巴胺释放，但不抑制腹侧纹状体的多巴胺释放。一致地，对纹状体背侧(而不是腹侧)中的多巴胺可兴奋细胞进行细胞特异性消融，抑制了糖驱动不适溶液摄取的能力。相反，对背侧而不是腹侧的多巴胺可兴奋细胞的光遗传刺激取代了糖，因为它能够驱动不合口味的溶液的摄取。我们的数据表明，糖招募了一个分布式的多巴胺可兴奋的纹状体回路，它的作用是优先考虑能量寻求而不是味道质量。
Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is however unknown if sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We show in mice that separate basal ganglia circuitries mediate the hedonic and nutritional actions of sugar. We found that, during sugar intake, suppressing hedonic value inhibited dopamine release in ventral but not dorsal striatum, whereas suppressing nutritional value inhibited dopamine release in dorsal but not ventral striatum. Consistently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar’s ability to drive the ingestion of unpalatable solutions. Conversely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum substituted for sugar in its ability to drive the ingestion of unpalatable solutions. Our data demonstrate that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize energy seeking over taste quality.