Structural diversity of leucine-rich repeat proteins
Structural diversity of leucine-rich repeat proteins
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DOI：
10.1006/jmbi.1998.1643
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发表时间：
1998-04-03
影响因子：
5.6
通讯作者：
Kajava, AV
中科院分区：
文献类型：
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作者：
Kajava, AV
富含亮氨酸的重复蛋白超家族可以细分为至少六个亚家族，其特征在于重复序列的不同长度和共有序列。有人提出，来自不同亚家族的重复序列保留相似的超螺旋折叠，但各个重复序列的三维结构不同。通过分子模型检查了三个新亚家族的序列-结构关系；我提供了所有亚科重复的结构模型。这些模型使我能够解释每个亚科内的残基保守性。此外，包装的差异解释了为什么来自不同亚家族的重复序列不会同时出现在同一蛋白质中。最后，这些研究表明不同亚科有不同的进化起源。用于预测富含亮氨酸的重复蛋白质结构的方法可以应用于含有长度约为20至SO残基的内部重复的其他蛋白质。 (C) 1998 学术出版社有限公司。
The superfamily of leucine-rich repeat proteins can be subdivided into at least six subfamilies, characterised by different lengths and consensus sequences of the repeats. It was proposed that the repeats from different subfamilies retain a similar superhelical fold, but differ in the three-dimensional structures of individual repeats. The sequence-structure relationship of three new subfamilies was examined by molecular modelling; I provide structural models for the repeats of all subfamilies. The models enable me to explain residue conservations within each subfamily. Furthermore, the difference in the packing explains why the repeats from different subfamilies never occur simultaneously in the same protein. Finally, these studies suggest different evolutionary origins for the different subfamilies. The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to SO residue in length. (C) 1998 Academic Press Limited.