National patterns of medication use during pregnancy
National patterns of medication use during pregnancy
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DOI：
10.1002/pds.1241
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发表时间：
2006-08-01
影响因子：
2.6
通讯作者：
Xue, Zhenyi
中科院分区：
文献类型：
--
作者：
Lee, Euni;Maneno, Mary K.;Xue, Zhenyi
目的 根据美国食品和药物管理局 (FDA) 妊娠风险分类，描述流动护理环境中怀孕期间的药物使用模式。 方法 对两项全国流动护理调查进行横断面研究，对 1999 年和 2000 年孕妇进行的所有就诊进行抽样。使用 FDA 妊娠风险分类，对药物使用模式和 FDA 妊娠风险 D 或 X (D/X) 药物的预测因素进行了评估。结果 在 1999 年和 2000 年，大约一半的孕妇就诊时使用了一种或多种药物。在总就诊次数中，FDA A 级占大多数（私人 = 65.7%；医院 = 79.5%；p < 0.05），其次是 C 级（私人 = 26.5%；医院 = 36.4%；p < 0.05）。 D/X 类药物分别占私人和医院就诊的 6.4% 和 2.9% (p < 0.05)。妊娠类别未知的药物在私人环境中占主导地位（12.0% 和 3.9%；p < 0.05）。年龄、保险类型、地区、医生专业和药物数量与 D/X 类别处方相关。在医院就诊中，来自西部地区和拥有私人保险的患者更有可能获得 D/X 类处方。在这两种情况下，药物的数量都与高风险药物密切相关。 结论 这项研究表明，孕妇的药物使用量相当大。使用 FDA 妊娠类别 D/X 药物就诊的比例为中等，但仍表明暴露于高风险药物。版权所有 (c) 2006 John Wiley & Sons, Ltd.
Purpose To describe patterns of medication use during pregnancy in ambulatory care settings according to the U.S. Food and Drug Administration (FDA) pregnancy risk classification.Methods A cross-sectional study of two national ambulatory care surveys, sampling all office visits made by pregnant women in 1999 and 2000, was conducted. Using the FDA pregnancy risk classification, patterns of medication use and predictive factors for FDA pregnancy risk D or X (D/X) medications were evaluated.Results In 1999 and 2000, about half of all pregnant visits had one or more medications. Among the total visits, FDA Class A was the majority (private = 65.7%; hospital = 79.5%; p < 0.05) followed by Class C (private = 26.5%; hospital = 36.4%; p < 0.05). Class D/X medications accounted for 6.4% and 2.9% of visits in private and hospital, respectively (p < 0.05). Medications with unknown pregnancy categories were predominant in the private setting (12.0% and 3.9%; p < 0.05). Age, insurance type, region, physician specialty, and number of medications were associated with a category D/X prescription. Among hospital visits, those from the West region and with private insurance were more likely to receive category D/X prescriptions. Number of medications was strongly associated with high-risk drugs in both settings.Conclusions This study shows considerable medication use among pregnant women. The prevalence of visits with FDA pregnancy category D/X drugs was moderate, but still indicates exposure to high-risk medications. Copyright (c) 2006 John Wiley & Sons, Ltd.