A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso
A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso
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DOI：
10.1186/1475-2875-12-79
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发表时间：
2013-02-27
期刊：
影响因子：
3
通讯作者：
Hamed, Kamal
中科院分区：
文献类型：
--
作者：
Tiono, Alfred B.;Ouedraogo, Alphonse;Hamed, Kamal
背景：在疟疾流行国家，很大比例的感染者没有症状，构成了新孵化蚊子感染寄生虫的宿主。本研究对恶性疟原虫无症状携带者的筛查和治疗效果进行了评价。方法：随机抽取18个村(1：1)，居民参加4次社区筛查活动：雨季前3次，间隔1个月；雨后4次，间隔12个月。在活动1-3的第一天，通过快速诊断试验确定干预组中的无症状携带者，并使用蒿甲醚-鲁米芬进行治疗。结果为症状性疟疾，寄生虫密度；儿童L每人每年5,000亩L儿童每人每年L
Background: In malaria-endemic countries, large proportions of infected individuals are asymptomatic, constituting a reservoir of parasites for infection of newly hatched mosquitoes. This study evaluated the impact of screening and treatment of asymptomatic carriers of Plasmodium falciparum.Methods: Eighteen villages were randomized (1: 1) to study arms and inhabitants participated in four community screening campaigns: three before the rainy season similar to 1 month apart, and the fourth after the rains at similar to 12 months. On day 1 of campaigns 1-3, asymptomatic carriers in the intervention arm were identified by rapid diagnostic test and treated with artemether-lumefantrine. Outcomes were symptomatic malaria with parasite density >5,000/mu L per person-year in children 5,000/mu L per person-year in children