Use of N-acetylglucosaminyltransferases I and II in the synthesis of a dideoxypentasaccharide.
Use of N-acetylglucosaminyltransferases I and II in the synthesis of a dideoxypentasaccharide.
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DOI：
10.1016/0968-0896(94)85017-8
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发表时间：
1994-07-01
影响因子：
3.5
通讯作者：
Hindsgaul, O
中科院分区：
文献类型：
--
作者：
Alton, G;Srivastava, G;Hindsgaul, O
依次使用部分纯化形式的N-乙酰葡糖胺转移酶I和II，将容易获得的合成6-脱氧-α-D-Man（1→3）[6-脱氧-α-D-Man（1→6）]β-D-Man-O（CH 2）2COOMe还原转化为所有复杂N-连接寡糖共有的五糖核心的双脱氧类似物。
Partially purified forms of N-acetylglucosaminyltransferases I and II were used, in sequence, to preparatively convert the readily available synthetic 6-deoxy-α-D-Man(1→3)[6-deoxy-α-D-Man(1→6)]β-D-Man-O(CH2)2COOMe to a dideoxy-analog of the pentasaccharide core common to all complex N-linked oligosaccharides.